Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding
Abstract: Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template‐based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia‐inducible transcription factor prolyl hydroxylase, PHD2.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding ; volume:25 ; number:8 ; year:2019 ; pages:2019-2024 ; extent:6
Chemistry - a European journal ; 25, Heft 8 (2019), 2019-2024 (gesamt 6)
- Creator
-
Thinnes, Cyrille C.
Lohans, Christopher T.
Abboud, Martine I.
Yeh, Tzu‐Lan
Tumber, Anthony
Nowak, Radosław P.
Attwood, Martin
Cockman, Matthew E.
Oppermann, Udo
Lönarz, Christoph
Schofield, Christopher
- DOI
-
10.1002/chem.201804790
- URN
-
urn:nbn:de:101:1-2022071407243677168751
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:31 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Thinnes, Cyrille C.
- Lohans, Christopher T.
- Abboud, Martine I.
- Yeh, Tzu‐Lan
- Tumber, Anthony
- Nowak, Radosław P.
- Attwood, Martin
- Cockman, Matthew E.
- Oppermann, Udo
- Lönarz, Christoph
- Schofield, Christopher
Other Objects (12)
Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
Prolyl-3-hydroxylase 1 in idiopathic pulmonary fibrosis
Prolyl hydroxylase inhibition prevents graft injury during liver transplantation
Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat
Novel Dioxygenases, HIF-α Specific Prolyl-hydroxylase and Asparanginyl-hydroxylase: O2 Switch for Cell Survival
Rolle der HIF-Prolyl Hydroxylase Enzyme in der akuten Pankreatitis
Modulation of prolyl hydroxylase domain (PHD) 2 in tumor inflammation
Impact of prolyl-4-hydroxylase deficiency on liver regeneration and sepsis
Bedeutung des HIF-Prolyl-Hydroxylase 1 (PHS1) Enzyms bei der Leberregeneration
Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase
Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice
Gas Tunnel Engineering of Prolyl Hydroxylase Reprograms Hypoxia Signaling in Cells
Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
Prolyl-3-hydroxylase 1 in idiopathic pulmonary fibrosis
Prolyl hydroxylase inhibition prevents graft injury during liver transplantation
Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat
Novel Dioxygenases, HIF-α Specific Prolyl-hydroxylase and Asparanginyl-hydroxylase: O2 Switch for Cell Survival
Rolle der HIF-Prolyl Hydroxylase Enzyme in der akuten Pankreatitis
Modulation of prolyl hydroxylase domain (PHD) 2 in tumor inflammation
Impact of prolyl-4-hydroxylase deficiency on liver regeneration and sepsis
Bedeutung des HIF-Prolyl-Hydroxylase 1 (PHS1) Enzyms bei der Leberregeneration
Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase
Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice
Gas Tunnel Engineering of Prolyl Hydroxylase Reprograms Hypoxia Signaling in Cells
Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding
Prolyl-3-hydroxylase 1 in idiopathic pulmonary fibrosis
Prolyl hydroxylase inhibition prevents graft injury during liver transplantation
Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat
Novel Dioxygenases, HIF-α Specific Prolyl-hydroxylase and Asparanginyl-hydroxylase: O2 Switch for Cell Survival
Rolle der HIF-Prolyl Hydroxylase Enzyme in der akuten Pankreatitis
Modulation of prolyl hydroxylase domain (PHD) 2 in tumor inflammation
Impact of prolyl-4-hydroxylase deficiency on liver regeneration and sepsis
Bedeutung des HIF-Prolyl-Hydroxylase 1 (PHS1) Enzyms bei der Leberregeneration
Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase
Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice