Factors Indicating Surgical Excision in Classical Type of Lobular Neoplasia of the Breast
Purpose: Classical type of lobular neoplasia (LN) encompassing both atypical lobular hyperplasia and classical lobular carcinoma in situ of the breast is a lesion with uncertain malignant potential and has been the topic of several studies with conflicting outcome results. The aim of our study was to clarify outcome-relevant factors and treatment options of classical LN. Methods: We performed a pathological re-evaluation of the preoperative biopsy specimens and a retrospective clinical and radiological data analysis of 160 patients with LN from the Breast Center Zurich. Open surgery was performed in 65 patients, vacuum-assisted biopsy (VAB) in 79 patients, and surveillance after breast core needle biopsy (CNB) in 16 patients. Results: The upgrade rate into ductal carcinoma in situ/invasive cancer was the highest in case of imaging/histology discordance (40%). If the number of foci in the biopsy specimen was ≥3, the upgrade rate in the consecutive surgical specimens was increased (p = 0.01). The association of classical LN with histological microcalcification correlated with shortened disease-free survival (p < 0.01), whereas other factors showed no impact on follow-up. Conclusions: Surveillance or subsequent VAB after CNB of LN is sufficient in most cases. Careful consideration of individual radiological and histological factors is required to identify patients with a high risk of upgrade into malignancy. In those cases, surgical excision is indicated.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Factors Indicating Surgical Excision in Classical Type of Lobular Neoplasia of the Breast ; volume:17 ; number:2 ; year:2022 ; pages:121-129 ; extent:9
Breast care ; 17, Heft 2 (2022), 121-129 (gesamt 9)
- Urheber
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Elfgen, Constanze
Tausch, Christoph
Rodewald, Ann-Katrin
Güth, Uwe
Rageth, Christoph
Bjelic-Radisic, Vesna
Fleisch, Markus
Kurtz, Claudia
Gonzalez Diaz, Jesus
Varga, Zsuzsanna
- DOI
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10.1159/000516609
- URN
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urn:nbn:de:101:1-2022050500313928790550
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:25 MESZ
Datenpartner
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Beteiligte
- Elfgen, Constanze
- Tausch, Christoph
- Rodewald, Ann-Katrin
- Güth, Uwe
- Rageth, Christoph
- Bjelic-Radisic, Vesna
- Fleisch, Markus
- Kurtz, Claudia
- Gonzalez Diaz, Jesus
- Varga, Zsuzsanna
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