Gold‐Induced Fibril Growth: The Mechanism of Surface‐Facilitated Amyloid Aggregation

to related objects

Abstract: The question of how amyloid fibril formation is influenced by surfaces is crucial for a detailed understanding of the process in vivo. We applied a combination of kinetic experiments and molecular dynamics simulations to elucidate how (model) surfaces influence fibril formation of the amyloid‐forming sequences of prion protein SUP35 and human islet amyloid polypeptide. The kinetic data suggest that structural reorganization of the initial peptide corona around colloidal gold nanoparticles is the rate‐limiting step. The molecular dynamics simulations reveal that partial physisorption to the surface results in the formation of aligned monolayers, which stimulate the formation of parallel, critical oligomers. The general mechanism implies that the competition between the underlying peptide–peptide and peptide–surface interactions must strike a balance to accelerate fibril formation.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Gold‐Induced Fibril Growth: The Mechanism of Surface‐Facilitated Amyloid Aggregation ; volume:55 ; number:37 ; year:2016 ; pages:11242-11246 ; extent:5
Angewandte Chemie / International edition. International edition ; 55, Heft 37 (2016), 11242-11246 (gesamt 5)

Creator: Gladytz, Anika
Abel, Bernd
Risselada, Herre Jelger

DOI: 10.1002/anie.201605151

URN: urn:nbn:de:101:1-2022101107480421782869

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:20 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Gladytz, Anika
Abel, Bernd
Risselada, Herre Jelger

Other Objects (12)

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Physical basis of amyloid fibril polymorphism

Protofibril–Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Hairpin trimer transition state of amyloid fibril

Amyloid fibril formation of the parathyroid hormone

The Prenucleation Equilibrium of the Parathyroid Hormone Determines the Critical Aggregation Concentration and Amyloid Fibril Nucleation

p53 amyloid aggregation in cancer: function, mechanism, and therapy

Hochschulschrift

Amyloid fibril-based hybrid materials: characterization and application

Photoinduced Amyloid Fibril Degradation for Controlled Cell Patterning

Cryo‑EM structure of a catalytic amyloid fibril

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Physical basis of amyloid fibril polymorphism

Protofibril–Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Hairpin trimer transition state of amyloid fibril

Amyloid fibril formation of the parathyroid hormone

The Prenucleation Equilibrium of the Parathyroid Hormone Determines the Critical Aggregation Concentration and Amyloid Fibril Nucleation

p53 amyloid aggregation in cancer: function, mechanism, and therapy

Hochschulschrift

Amyloid fibril-based hybrid materials: characterization and application

Photoinduced Amyloid Fibril Degradation for Controlled Cell Patterning

Cryo‑EM structure of a catalytic amyloid fibril

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Physical basis of amyloid fibril polymorphism

Protofibril–Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Hairpin trimer transition state of amyloid fibril

Amyloid fibril formation of the parathyroid hormone

The Prenucleation Equilibrium of the Parathyroid Hormone Determines the Critical Aggregation Concentration and Amyloid Fibril Nucleation

p53 amyloid aggregation in cancer: function, mechanism, and therapy

Hochschulschrift

Amyloid fibril-based hybrid materials: characterization and application

Photoinduced Amyloid Fibril Degradation for Controlled Cell Patterning

Cryo‑EM structure of a catalytic amyloid fibril

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

Gold‐Induced Fibril Growth: The Mechanism of Surface‐Facilitated Amyloid Aggregation

Object Details

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Physical basis of amyloid fibril polymorphism

Protofibril–Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Hairpin trimer transition state of amyloid fibril

Amyloid fibril formation of the parathyroid hormone

The Prenucleation Equilibrium of the Parathyroid Hormone Determines the Critical Aggregation Concentration and Amyloid Fibril Nucleation

p53 amyloid aggregation in cancer: function, mechanism, and therapy

Amyloid fibril-based hybrid materials: characterization and application

Photoinduced Amyloid Fibril Degradation for Controlled Cell Patterning

Cryo‑EM structure of a catalytic amyloid fibril

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Physical basis of amyloid fibril polymorphism

Protofibril–Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Hairpin trimer transition state of amyloid fibril

Amyloid fibril formation of the parathyroid hormone

The Prenucleation Equilibrium of the Parathyroid Hormone Determines the Critical Aggregation Concentration and Amyloid Fibril Nucleation

p53 amyloid aggregation in cancer: function, mechanism, and therapy

Amyloid fibril-based hybrid materials: characterization and application

Photoinduced Amyloid Fibril Degradation for Controlled Cell Patterning

Cryo‑EM structure of a catalytic amyloid fibril

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

Physical basis of amyloid fibril polymorphism

Protofibril–Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation

An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Hairpin trimer transition state of amyloid fibril

Amyloid fibril formation of the parathyroid hormone

The Prenucleation Equilibrium of the Parathyroid Hormone Determines the Critical Aggregation Concentration and Amyloid Fibril Nucleation

p53 amyloid aggregation in cancer: function, mechanism, and therapy

Amyloid fibril-based hybrid materials: characterization and application

Photoinduced Amyloid Fibril Degradation for Controlled Cell Patterning

Cryo‑EM structure of a catalytic amyloid fibril

Related objects

Reset password