Diabetic cardiomyopathy: does the type of diabetes matter?

Abstract: In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that parallels the increased prevalence of obesity and which markedly increases the risk of cardiovascular disease across the globe. While ischemic heart disease represents the major cause of death in diabetic subjects, diabetic cardiomyopathy (DC) summarizes adverse effects of diabetes mellitus on the heart that are independent of coronary artery disease (CAD) and hypertension. DC increases the risk of heart failure (HF) and may lead to both heart failure with preserved ejection fraction (HFpEF) and reduced ejection fraction (HFrEF). Numerous molecular mechanisms have been proposed to underlie DC that partially overlap with mechanisms believed to contribute to heart failure. Nevertheless, the existence of DC remains a topic of controversy, although the clinical relevance of DC is increasingly recognized by scientists and clinicians. In addition, relatively little attention has been attributed to the fact that both underlying mechanisms and clinical features of DC may be partially distinct in type 1 versus type 2 diabetes. In the following review, we will discuss clinical and preclinical literature on the existence of human DC in the context of the two different types of diabetes mellitus

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
International journal of molecular sciences. 17, 12 (2016), 2136, DOI 10.3390/ijms17122136, issn: 1422-0067
IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs

Keyword
Herzmuskelkrankheit
Herz
Diabetes mellitus
Endokrinologie

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2016

DOI
10.3390/ijms17122136
URN
urn:nbn:de:bsz:25-freidok-131999
Rights
Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
25.03.2025, 1:43 PM CET

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Time of origin

  • 2016

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