Electrohydrodynamic Printing of Biodegradable PLGA Micro‐Patterns on 3D Polymer Structures

Abstract: Biodegradable polymers such as polylactic‐co‐glycolic acids (PLGA) are used for various implantable devices such as tissue scaffolds, drug delivery devices, and biosensors in different forms. However, high‐resolution patterning of biodegradable polymers on implantable devices has not been explored much yet. While electrohydrodynamic printing (EHD) can achieve high‐resolution printing compared to other printing methods, EHD printing of PLGA solutions is rarely attempted due to unstable printing. Such printing instability originates from the volatile nature of PLGA inks, and it causes nozzle clogging or change of ink conditions during printing. Here, PLGA ink formulation and a voltage input profile are studied for stable and high‐resolution EHD printing. Addition of glycerol at an optimal ratio as well as the control of voltage pulse shape strongly influenced both the stability and resolution of EHD printing of PLGA patterns. With the optimized inks and voltage inputs, stable printing of PLGA micropatterns down to 5 µm is achieved on both conductive and insulating surfaces for controlled drug release. Furthermore, use of a ring type electrode allows for EHD printing of PLGA micropatterns on 3D surfaces of PLLA tubes and stent struts.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Electrohydrodynamic Printing of Biodegradable PLGA Micro‐Patterns on 3D Polymer Structures ; day:30 ; month:07 ; year:2024 ; extent:9
Advanced Materials Technologies ; (30.07.2024) (gesamt 9)

Creator
Seo, IlHo
Hassan, Rizwan Ul
Ryu, Byeongseok
Koh, Won‐Gun
Ryu, WonHyoung

DOI
10.1002/admt.202400230
URN
urn:nbn:de:101:1-2407311404167.710800778149
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
14.08.2025, 10:54 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Associated

  • Seo, IlHo
  • Hassan, Rizwan Ul
  • Ryu, Byeongseok
  • Koh, Won‐Gun
  • Ryu, WonHyoung

Other Objects (12)