Update on Hepatobiliary Plasticity

Abstract: The liver field has been debating for decades the contribution of the plasticity of the two epithelial compartments in the liver, hepatocytes and biliary epithelial cells (BECs), to derive each other as a repair mechanism. The hepatobiliary plasticity has been first observed in diseased human livers by the presence of biphenotypic cells expressing hepatocyte and BEC markers within bile ducts and regenerative nodules or budding from strings of proliferative BECs in septa. These observations are not surprising as hepatocytes and BECs derive from a common fetal progenitor, the hepatoblast, and, as such, they are expected to compensate for each other's loss in adults. To investigate the cell origin of regenerated cell compartments and associated molecular mechanisms, numerous murine and zebrafish models with ability to trace cell fates have been extensively developed. This short review summarizes the clinical and preclinical studies illustrating the hepatobiliary plasticity and its potential therapeutic application.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Update on Hepatobiliary Plasticity ; volume:43 ; number:01 ; year:2023 ; pages:013-023 ; Seminars in liver disease ; 43, Heft 01 (2023), 013-023

Contributors, Places and Time

• Contributor: Kim, Minwook ; Rizvi, Fatima ; Shin, Donghun ; Gouon-Evans, Valerie

Further information

• DOI: 10.1055/s-0042-1760306
• URN: urn:nbn:de:101:1-2023042715024687207592
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:45 AM CEST