Cells‐Micropatterning Biomaterials for Immune Activation and Bone Regeneration
Abstract: Natural tissues are composed of ordered architectural organizations of multiple tissue cells. The spatial distribution of cells is crucial for directing cellular behavior and maintaining tissue homeostasis and function. Herein, an artificial bone bioceramic scaffold with star‐, Tai Chi‐, or interlacing‐shaped multicellular patterns is constructed. The “cross‐talk” between mesenchymal stem cells (MSCs) and macrophages can be effectively manipulated by altering the spatial distribution of two kinds of cells in the scaffolds, thus achieving controllable modulation of the scaffold‐mediated osteo‐immune responses. Compared with other multicellular patterns, the Tai Chi pattern with a 2:1 ratio of MSCs to macrophages is more effective in activating anti‐inflammatory M2 macrophages, improving MSCs osteogenic differentiation, and accelerating new bone formation in vivo. In brief, the Tai Chi pattern generates a more favorable osteo‐immune environment for bone regeneration, exhibiting enhanced immunomodulation and osteogenesis, which may be associated with the activation of BMP‐Smad, Oncostatin M (OSM), and Wnt/β‐catenin signaling pathways in MSCs mediated by macrophage‐derived paracrine signaling mediators. The study suggests that the manipulation of cell distribution to improve tissue formation is a feasible approach that can offer new insights for the design of tissue‐engineered bone substitutes with multicellular interactions.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Cells‐Micropatterning Biomaterials for Immune Activation and Bone Regeneration ; day:28 ; month:04 ; year:2022 ; extent:15
Advanced science ; (28.04.2022) (gesamt 15)
- Creator
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Zhang, Bingjun
Han, Fei
Wang, Yufeng
Sun, Yuhua
Zhang, Meng
Yu, Xiaopeng
Qin, Chen
Zhang, Hongjian
Wu, Chengtie
- DOI
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10.1002/advs.202200670
- URN
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urn:nbn:de:101:1-2022042815115126922787
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhang, Bingjun
- Han, Fei
- Wang, Yufeng
- Sun, Yuhua
- Zhang, Meng
- Yu, Xiaopeng
- Qin, Chen
- Zhang, Hongjian
- Wu, Chengtie
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