Neuartige Zielvolumendefinition für die Strahlentherapie des Glioblastoma multiforme
Abstract: Background: For target delineation in Glioblastoma there are currently two major consensus guidelines being used, the one of the European Organisation for Research and Treatment of Cancer (EORTC) and the one of the Radiation Therapy Oncology Group (RTOG). The resulting target volumes are often large and lead to irradiation of healthy brain tissue.
Objective: Primary aim was the analysis of the recurrence pattern in relation to three different target volumes and their volumetric comparison. Since hypothetically recurrences mostly occur locally, it was investigated whether the irradiation volume can be reduced to spare healthy tissue and possibly reduce side effects.
Methods: A total of 89 patient data were evaluated using the iPlan radiation planning system and the statistics software SPSS®. Magnetic resonance imaging (MRI) scans from the time of radiation treatment planning were compared with those at the first occurrence of recurrence. Considering changes in T2/fluid-attenuated inversion recovery (FLAIR) sequences on MRI, a novel reduced target volume (PTVNeu) was defined and compared to the conventional methods of EORTC and RTOG.
Results: The recurrence pattern of the reduced target volume was comparable to that of the EORTC method. The number of in-field recurrences was 79.5 % vs. 80.8 %, 11 % vs. 8.9 % for marginal recurrences, and 9.6 % vs. 10.3 % for out-of-field recurrences. The reduced target volume with a median of 179 ml was significantly smaller than the target volumes by EORTC and RTOG method (292.9 ml and 452.9 ml, p<0.001).
Conclusions: Even with a reduced target volume, most recurrences are located in-field with respect to the PTV. Compared with the conventional methods significantly less surrounding tissue would be irradiated. The results validate the use of reduced irradiation volumes in prospective studies for possible future consolidation of target volume reduction
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Deutsch
- Notes
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Universität Freiburg, Dissertation, 2025
- Keyword
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ICD
Strahlentherapie
Glioblastom
Glioblastom
Strahlentherapie
Bestrahlungsplan
Bestrahlung
neu
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2025
- Creator
- Contributor
- DOI
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10.6094/UNIFR/262183
- URN
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urn:nbn:de:bsz:25-freidok-2621833
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:20 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Time of origin
- 2025
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