Proline‐Functionalized Magnetic Nanoparticles as Highly Performing Asymmetric Catalysts

Abstract: Amino acids have a crucial role in the field of asymmetric organocatalysis for the production of chiral compounds with high added value and specific biological activity. In particular, proline offers high activity and stereoselectivity for catalyzing aldol reactions in organic solvents. However, proline‐based catalysts often lack water‐solubility, accessibility, catalytic performance, or recovery in aqueous media. This work reports the design of proline‐functionalized poly (methyl methacrylate) (PMMA) nanoparticles with a magnetic core that offer high availability of chiral units in water and high recyclability. A proline‐based copolymerizable surfactant is designed and integrated onto the surface of PMMA nanoparticles through a miniemulsion polymerization process without using additional surfactants. The miniemulsion technique allows the incorporation of magnetite to the system to create a magnetically separable catalyst. The chiral nanocatalyst presents a high diastereoselective catalytic activity for the intermolecular aldol reaction between p‐nitrobenzaldehyde and cyclohexanone in water.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Proline‐Functionalized Magnetic Nanoparticles as Highly Performing Asymmetric Catalysts ; day:11 ; month:09 ; year:2024 ; extent:9 ; Macromolecular rapid communications ; (11.09.2024) (gesamt 9)

Contributors, Places and Time

• Creator: Álvarez‐Bermúdez, Olaia ; Landfester, Katharina ; Zhang, Kai A. I. ; Muñoz-Espí, Rafael

Further information

• DOI: 10.1002/marc.202400615
• URN: urn:nbn:de:101:1-2409121405400.159923241279
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:37 AM CEST