An Organometallic Umpolung Approach for Iron‐Mediated Propargylic C−H Etherification
Abstract: Propargylic ethers serve as useful intermediates for the synthesis of a variety of complex targets. However, propargylic substitution of prefunctionalized alkyne starting materials remains the dominant method for the synthesis of propargyl ethers, while direct etherification of simple alkynes via propargylic C−H functionalization remains largely underreported. Herein, we report an organometallic umpolung approach for iron‐mediated C−H propargylic etherification. A telescopic protocol for iron‐mediated C−H deprotonation followed by mild oxidative coupling with alcohols enabled the use of simple or functionalized alkynes for the expedient synthesis of propargylic ethers with excellent functional group compatibility, chemoselectivity and regioselectivity.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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An Organometallic Umpolung Approach for Iron‐Mediated Propargylic C−H Etherification ; day:20 ; month:11 ; year:2024 ; extent:8
Angewandte Chemie ; (20.11.2024) (gesamt 8)
- Creator
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Xia, Yue
Zhu, Jin
Durham, Austin C.
Wang, Yi‐Ming
- DOI
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10.1002/ange.202413017
- URN
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urn:nbn:de:101:1-2411211344311.948165169333
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:35 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Xia, Yue
- Zhu, Jin
- Durham, Austin C.
- Wang, Yi‐Ming
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