Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease
Abstract: Parkinson's disease (PD) is a common chronic central nervous system disorder that reduces quality of life and increases mortality. Currently, the treatment of PD is limited due to the challenge of macromolecular drugs crossing the blood‐brain barrier (BBB). Black phosphorus (BP) has antioxidant and anti‐inflammatory effects and shows potential for neuroprotection. To solve the restriction of the BBB, innovative BP microbubbles (BP@MBs) combined with focused ultrasound (FUS) are constructed to facilitate BBB opening. Additionally, the biocompatibility and safety of BP@MBs with varying dimensions are investigated, including BP quantum dot microbubbles (BPQDs@MBs) and BP nanosheet microbubbles (BPNSs@MBs). The findings indicate that low concentrations of BP have good biosafety and that BPQDs@MBs exhibit better biocompatibility than BPNSs@MBs both in vitro and in vivo at the same concentrations. Moreover, a 6‐hydroxydopamine (6‐OHDA)‐induced PD cell model and an animal model are established to verify the anti‐PD effects of BPQDs@MBs and BPNSs@MBs. The results confirmed that BPQDs@MBs and BPNSs@MBs have antioxidant effects that reduced neuronal apoptosis and improved the motor symptoms of PD in rats. BPQDs@MBs combined with FUS may be a promising option for the clinical treatment of PD.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Black Phosphorus Microbubbles Combined with Ultrasound for Treating Parkinson's Disease ; day:07 ; month:03 ; year:2024 ; extent:20
Advanced therapeutics ; (07.03.2024) (gesamt 20)
- Creator
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Guo, Shuyuan
Zhang, Zhuxia
Xu, Bingxuan
Wang, Mengxin
Fan, Taojian
Zhong, Xinliang
Hu, Azhen
Hu, Die
Luo, Lan
Lin, Shuping
Wang, Linlin
Yao, Rongquan
Huang, Jiabao
Hu, Huiying
Shuai, Xintao
Shi, Jie
Chen, Yun
Zheng, Tingting
- DOI
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10.1002/adtp.202300254
- URN
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urn:nbn:de:101:1-2024030713350113491006
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:50 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Guo, Shuyuan
- Zhang, Zhuxia
- Xu, Bingxuan
- Wang, Mengxin
- Fan, Taojian
- Zhong, Xinliang
- Hu, Azhen
- Hu, Die
- Luo, Lan
- Lin, Shuping
- Wang, Linlin
- Yao, Rongquan
- Huang, Jiabao
- Hu, Huiying
- Shuai, Xintao
- Shi, Jie
- Chen, Yun
- Zheng, Tingting
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