Artikel
Optimal CAR T-cell immunotherapy strategies for a leukemia treatment model
CAR T-cell immunotherapy is a new development in the treatment of leukemia, promising a new era in oncology. Although so far, this procedure only helps 50-90% of patients and, like other cancer treatments, has serious side effects. In this work, we have proposed a controlled model for leukemia treatment to explore possible ways to improve immunotherapy methodology. Our model is described by four nonlinear differential equations with two bounded controls, which are responsible for the rate of injection of chimeric cells, as well as for the dosage of the drug that suppresses the so-called "cytokine storm". The optimal control problem of minimizing the cancer cells and the activity of the cytokine is stated and solved using the Pontryagin maximum principle. The five possible optimal control scenarios are predicted analytically using investigation of the behavior of the switching functions. The optimal solutions, obtained numerically using BOCOP-2.2.0, confirmed our analytical findings. Interesting results, explaining, why therapies with rest intervals (for example, stopping injections in the middle of the treatment interval) are more effective (within the model), rather than with continuous injections, are presented. Possible improvements to the mathematical model and method of immunotherapy are discussed.
- Language
-
Englisch
- Bibliographic citation
-
Journal: Games ; ISSN: 2073-4336 ; Volume: 11 ; Year: 2020 ; Issue: 4 ; Pages: 1-26 ; Basel: MDPI
- Classification
-
Wirtschaft
- Subject
-
Generalized Rolle's Theorem
leukemia
nonlinear control system
optimal control
Pontryagin maximum principle
switching function
- Event
-
Geistige Schöpfung
- (who)
-
Khailov, Evgenii
Grigorieva, Ellina
Klimenkova, Anna
- Event
-
Veröffentlichung
- (who)
-
MDPI
- (where)
-
Basel
- (when)
-
2020
- DOI
-
doi:10.3390/g11040053
- Handle
- Last update
-
10.03.2025, 11:41 AM CET
Data provider
ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften - Leibniz-Informationszentrum Wirtschaft. If you have any questions about the object, please contact the data provider.
Object type
- Artikel
Associated
- Khailov, Evgenii
- Grigorieva, Ellina
- Klimenkova, Anna
- MDPI
Time of origin
- 2020
Other Objects (12)
Manipulating the metabolism to improve the efficacy of CAR T-cell immunotherapy
Human T-cell leukemia virus
CAR T-Cell therapy
Identification of Suitable T-Cell Subsets for Personalized Antiviral T-Cell Immunotherapy
Next-generation immunotherapy to counteract T-cell exhaustion
The role of T-cell exhaustion for cancer immunotherapy
The T-cell receptor and it's signaling in T-cell prolymphocytic Leukemia
T-cell interaction with leukemia in the bone marrow of pediatric patients with T-cell acute lymphoblastic leukemia
Evaluation of T-cell receptor reprogrammed natural killer cells as an "off the shelf" adoptive cellular immunotherapy against acute myeloid leukemia
Heterogeneity of HBV-specific CD8+ T-cell failure: implications for immunotherapy
Engineered extracellular vesicles for immunotherapy of chronic lymphocytic leukemia (CLL)
From small molecule to cellular immunotherapy: therapeutic approaches for leukemia
Manipulating the metabolism to improve the efficacy of CAR T-cell immunotherapy
Human T-cell leukemia virus
CAR T-Cell therapy
Identification of Suitable T-Cell Subsets for Personalized Antiviral T-Cell Immunotherapy
Next-generation immunotherapy to counteract T-cell exhaustion
The role of T-cell exhaustion for cancer immunotherapy
The T-cell receptor and it's signaling in T-cell prolymphocytic Leukemia
T-cell interaction with leukemia in the bone marrow of pediatric patients with T-cell acute lymphoblastic leukemia
Evaluation of T-cell receptor reprogrammed natural killer cells as an "off the shelf" adoptive cellular immunotherapy against acute myeloid leukemia
Heterogeneity of HBV-specific CD8+ T-cell failure: implications for immunotherapy
Engineered extracellular vesicles for immunotherapy of chronic lymphocytic leukemia (CLL)
From small molecule to cellular immunotherapy: therapeutic approaches for leukemia
Manipulating the metabolism to improve the efficacy of CAR T-cell immunotherapy
Human T-cell leukemia virus
CAR T-Cell therapy
Identification of Suitable T-Cell Subsets for Personalized Antiviral T-Cell Immunotherapy
Next-generation immunotherapy to counteract T-cell exhaustion
The role of T-cell exhaustion for cancer immunotherapy
The T-cell receptor and it's signaling in T-cell prolymphocytic Leukemia
T-cell interaction with leukemia in the bone marrow of pediatric patients with T-cell acute lymphoblastic leukemia
Evaluation of T-cell receptor reprogrammed natural killer cells as an "off the shelf" adoptive cellular immunotherapy against acute myeloid leukemia
Heterogeneity of HBV-specific CD8+ T-cell failure: implications for immunotherapy
Engineered extracellular vesicles for immunotherapy of chronic lymphocytic leukemia (CLL)