Single‐Cell RNA Sequencing Uncovers Pathological Processes and Crucial Targets for Vascular Endothelial Injury in Diabetic Hearts
Abstract: Cardiovascular disease remains the leading cause of high mortality in individuals with diabetes mellitus. Endothelial injury is a major contributing factor for vascular dysfunction in diabetes. However, the precise mechanisms underlying endothelial cell injury and their heterogeneity in diabetes remains elusive. In this study, single‐cell sequencing is performed in heart tissues from leptin receptor knock‐out (db/db) diabetic mice at various pathological stages. Through cell cluster identification, differential gene analysis, intercellular communication analysis, pseudo time analysis, and transcription factor analysis, a novel mechanism of cardiac vascular endothelial damage in diabetes is identified. Specifically, a single‐cell transcription map of cardiac vascular endothelial cells is presented in db/db mice. Diverse cellular clusters are found to play vital roles under diabetes‐induced damage, highlighting crucial transcription factors involved in their regulation. In addition, the essential transcription factor Ets1 is found to protect against vascular endothelial injury in db/db mice. In summary, the work provides a comprehensive understanding of the development of diabetic cardiac vascular endothelial damage and the heterogeneity of the cells involved. These findings offer valuable insights into potential treatments and assessments of diabetic cardiovascular endothelial damage.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Single‐Cell RNA Sequencing Uncovers Pathological Processes and Crucial Targets for Vascular Endothelial Injury in Diabetic Hearts ; day:30 ; month:10 ; year:2024 ; extent:14
Advanced science ; (30.10.2024) (gesamt 14)
- Urheber
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Zhang, Yan
Cao, Yang
Zhang, Xuebin
Lin, Jie
Jiang, Mengyuan
Zhang, Xiao
Dai, Xinchun
Zhang, Xiaohua
Liu, Yue
Ge, Wen
Qiang, Huanhuan
Li, Congye
Sun, Dongdong
- DOI
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10.1002/advs.202405543
- URN
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urn:nbn:de:101:1-2410301413056.882907005151
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:27 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zhang, Yan
- Cao, Yang
- Zhang, Xuebin
- Lin, Jie
- Jiang, Mengyuan
- Zhang, Xiao
- Dai, Xinchun
- Zhang, Xiaohua
- Liu, Yue
- Ge, Wen
- Qiang, Huanhuan
- Li, Congye
- Sun, Dongdong
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