Microflow system promotes acetaminophen crystal nucleation
Abstract: It is known that interfaces have various impacts on crystallization from a solution. Here, we describe crystallization of acetaminophen using a microflow channel, in which two liquids meet and form a liquid–liquid interface due to laminar flow, resulting in uniform mixing of solvents on the molecular scale. In the anti‐solvent method, the microflow mixing promoted the crystallization more than bulk mixing. Furthermore, increased flow rate encouraged crystal formation, and a metastable form appeared under a certain flow condition. This means that interface management by the microchannel could be a beneficial tool for crystallization and polymorph control.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Microflow system promotes acetaminophen crystal nucleation ; volume:20 ; number:9-10 ; year:2020 ; pages:395-401 ; extent:7
Engineering in life sciences ; 20, Heft 9-10 (2020), 395-401 (gesamt 7)
- Creator
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Nishigaki, Akari
Maruyama, Mihoko
Numata, Munenori
Kanzaki, Chisako
Tanaka, Shun‐Ichi
Yoshikawa, Hiroshi Y.
Imanishi, Masayuki
Yoshimura, Masashi
Mori, Yusuke
Takano, Kazufumi
- DOI
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10.1002/elsc.202000021
- URN
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urn:nbn:de:101:1-2022062407330178030323
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
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Associated
- Nishigaki, Akari
- Maruyama, Mihoko
- Numata, Munenori
- Kanzaki, Chisako
- Tanaka, Shun‐Ichi
- Yoshikawa, Hiroshi Y.
- Imanishi, Masayuki
- Yoshimura, Masashi
- Mori, Yusuke
- Takano, Kazufumi
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Monte Carlo simulations of nucleation of colloidal crystals
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Struvite nucleation and crystal growth kinetics from cattle liquid manure
Vortices nucleation by inherent fluctuations in nematic liquid crystal cells
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Phase behavior, crystal nucleation, and interactions in colloidal model systems
Numerical study of homogeneous and heterogeneous crystal nucleation in colloidal systems
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Struvite nucleation and crystal growth kinetics from cattle liquid manure
Vortices nucleation by inherent fluctuations in nematic liquid crystal cells
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