Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis
Abstract: Plant‐derived diterpenoids serve as important pharmaceuticals, food additives, and fragrances, yet their low natural abundance and high structural complexity limits their broader industrial utilization. By mimicking the modularity of diterpene biosynthesis in plants, we constructed 51 functional combinations of class I and II diterpene synthases, 41 of which are “new‐to‐nature”. Stereoselective biosynthesis of over 50 diterpene skeletons was demonstrated, including natural variants and novel enantiomeric or diastereomeric counterparts. Scalable biotechnological production for four industrially relevant targets was accomplished in engineered strains of Saccharomyces cerevisiae.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis ; volume:128 ; number:6 ; year:2016 ; pages:2182-2186 ; extent:5
Angewandte Chemie ; 128, Heft 6 (2016), 2182-2186 (gesamt 5)
- Creator
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Andersen‐Ranberg, Johan
Kongstad, Kenneth Thermann
Nielsen, Morten Thrane
Jensen, Niels Bjerg
Pateraki, Irini
Bach, Søren Spanner
Hamberger, Britta
Zerbe, Philipp
Staerk, Dan
Bohlmann, Jörg
Møller, Birger Lindberg
Hamberger, Björn
- DOI
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10.1002/ange.201510650
- URN
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urn:nbn:de:101:1-2022101106410409480202
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
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Associated
- Andersen‐Ranberg, Johan
- Kongstad, Kenneth Thermann
- Nielsen, Morten Thrane
- Jensen, Niels Bjerg
- Pateraki, Irini
- Bach, Søren Spanner
- Hamberger, Britta
- Zerbe, Philipp
- Staerk, Dan
- Bohlmann, Jörg
- Møller, Birger Lindberg
- Hamberger, Björn
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Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis
Expanding the Chemical Diversity of the Antitumoral Compound Mithramycin by Combinatorial Biosynthesis and Biocatalysis: The Quest for Mithralogs with Improved Therapeutic Window
Designing and Expanding Electrical Networks – Complexity and Combinatorial Algorithms
The Combinatorial Biosynthesis of “Unnatural” Products with Polyketides
Combinatorial biosynthesis of novel aminoglycoside antibiotics via pathway engineering
Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning
The expanding CML treatment landscape: an introspective commentary
Combinatorial functional diversity: an information theoretical approach
Expanding diversity of bunyaviruses identified in mosquitoes
Combinatorial engineering of betalain biosynthesis pathway in yeast Saccharomyces cerevisiae
Combinatorial biosynthesis for the engineering of novel fungal natural products
Biosynthesis pathways of expanding carbon chains for producing advanced biofuels
Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis
Expanding the Chemical Diversity of the Antitumoral Compound Mithramycin by Combinatorial Biosynthesis and Biocatalysis: The Quest for Mithralogs with Improved Therapeutic Window
Designing and Expanding Electrical Networks – Complexity and Combinatorial Algorithms
The Combinatorial Biosynthesis of “Unnatural” Products with Polyketides
Combinatorial biosynthesis of novel aminoglycoside antibiotics via pathway engineering
Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning
The expanding CML treatment landscape: an introspective commentary
Combinatorial functional diversity: an information theoretical approach
Expanding diversity of bunyaviruses identified in mosquitoes
Combinatorial engineering of betalain biosynthesis pathway in yeast Saccharomyces cerevisiae
Combinatorial biosynthesis for the engineering of novel fungal natural products