Peripheral polyneuropathy from electrodiagnostic tests: a 10-year etiology and neurophysiology overview

Abstract: Background: Polyneuropathies are characterized by a symmetrical impairment of the peripheral nervous system, resulting in sensory, motor and/or autonomic deficits. Due to the heterogeneity of causes, an etiological diagnosis for polyneuropathy is challenging. Objective: The aim of this study was to determine the main causes of polyneuropathy confirmed by electrodiagnostic (EDX) tests in a tertiary service and its neurophysiological aspects. Methods: This observational cross-sectional study from a neuromuscular disorders center included individuals whose electrodiagnostic tests performed between 2008 and 2017 confirmed a diagnosis of polyneuropathy. Through analysis of medical records, polyneuropathies were classified according to etiology and neurophysiological aspect. Results: Of the 380 included patients, 59.5% were male, with a median age of 43 years. The main etiologies were: inflammatory (23.7%), hereditary (18.9%), idiopathic (13.7%), multifactorial (11.1%), and diabetes (10.8%). The main electrophysiological patterns were axonal sensorimotor polyneuropathy (36.1%) and “demyelinating and axonal” sensorimotor polyneuropathy (27.9%). Axonal patterns showed greater etiological heterogeneity, with a predominance of idiopathic and multifactorial polyneuropathy, while demyelinating and “demyelinating and axonal” polyneuropathies had a significantly fewer etiologies, with a predominance of hereditary and inflammatory polyneuropathies. Conclusion: The main causes of polyneuropathy confirmed by EDX test in this study were those that presented a severe, atypical and/or rapidly progressing pattern. Other causes were hereditary and those that defy clinical reasoning, such as multiple risk factors; some polyneuropathies did not have a specific etiology. EDX tests are useful for etiological diagnosis of rare polyneuropathies, because neurophysiological patterns are correlated with specific etiologies.

Angaben zum Objekt

• Weitere Titel: Polineuropatia periférica confirmada pela eletroneuromiografia: um panorama de 10 anos baseado na etiologia e neurofisiologia
• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Peripheral polyneuropathy from electrodiagnostic tests: a 10-year etiology and neurophysiology overview ; volume:80 ; number:03 ; year:2022 ; pages:270-279 ; Arquivos de neuro-psiquiatria ; 80, Heft 03 (2022), 270-279

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: Ducci, Renata Dal-Prá ; Tessaro, Camila Lorenzini ; Kay, Cláudia Suemi Kamoi ; Fustes, Otto Jesus Hernandez ; Werneck, Lineu Cesar ; Lorenzoni, Paulo José ; Scola, Rosana Herminia

Weitere Informationen

• DOI: 10.1590/0004-282X-ANP-2020-0561
• URN: urn:nbn:de:101:1-2023031611021618809130
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:49 MESZ