Chemo‐Enzymatic Synthesis of Pyrazines and Pyrroles
Abstract: Herein we report the biocatalytic synthesis of substituted pyrazines and pyrroles using a transaminase (ATA) to mediate the key amination step of the ketone precursors. Treatment of α‐diketones with ATA‐113 in the presence of a suitable amine donor yielded the corresponding α‐amino ketones which underwent oxidative dimerization to the pyrazines. Selective amination of α‐diketones in the presence of β‐keto esters afforded substituted pyrroles in a biocatalytic equivalent of the classical Knorr pyrrole synthesis. Finally we have shown that pyrroles can be prepared by internal amine transfer catalyzed by a transaminase in which no external amine donor is required.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Chemo‐Enzymatic Synthesis of Pyrazines and Pyrroles ; volume:57 ; number:51 ; year:2018 ; pages:16760-16763 ; extent:4
Angewandte Chemie / International edition. International edition ; 57, Heft 51 (2018), 16760-16763 (gesamt 4)
- Urheber
- DOI
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10.1002/anie.201810555
- URN
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urn:nbn:de:101:1-2022090305431355346712
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:26 MESZ
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Beteiligte
- Xu, Jin
- Green, Anthony P.
- Turner, Nicholas J.
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