One‐Step Method for Instant Generation of Advanced Allogeneic NK Cells

zu Verbundenen Objekten

Abstract: Conventional combinatorial anticancer therapy has shown promising outcomes; still, a significant interest in developing new methods to reinforce and possibly merge chemotherapy and immunotherapy persists. Here, a new one‐step method that immediately modifies immune cells into a targeted form of chemoimmunotherapy through spontaneous and rapid incorporation of hydrophobized antibody–drug conjugates (ADCs) on the surface of immune cells is presented. Therapeutic objectives of this approach include targeted delivery of a potent chemotherapeutic agent to avoid adverse effects, enhancing the mobilization of infused immune cells toward tumor sites, and preserving the intense cytotoxic activities of immune cells against tumor cells. The embedding of hydrophobized ADCs on the immune cell membrane using the strategy in this study provides noninvasive, nontoxic, and homogenous modifications that transiently arm immune cells with highly potent cytotoxic drugs targeted toward cancer cells. The resulting surface‐engineered immune cells with ADCs significantly suppress the tumor growth and drive the eradication of target cancer cells through combinatorial anticancer effects. This novel strategy allows convenient and timely preparation of advanced chemoimmunotherapy on a single immune cell to treat various types of cancer.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
One‐Step Method for Instant Generation of Advanced Allogeneic NK Cells ; volume:5 ; number:11 ; year:2018 ; extent:11
Advanced science ; 5, Heft 11 (2018) (gesamt 11)

Urheber
Lee, Daniel Y.
Lim, Kwang Suk
Valencia, Gabriel M.
Jung, Minjin
Bull, David A.
Won, Young‐Wook

DOI
10.1002/advs.201800447
URN
urn:nbn:de:101:1-2022090806131104944706
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:34 MESZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Original beim Datenpartner anzeigen

Beteiligte

  • Lee, Daniel Y.
  • Lim, Kwang Suk
  • Valencia, Gabriel M.
  • Jung, Minjin
  • Bull, David A.
  • Won, Young‐Wook

Ähnliche Objekte (12)

Elektrisch, nur elektrisch : One-Step

Schellackplatte

Elektrisch, nur elektrisch : One-Step

One-step mechanosynthesis of nanocrystalline oxides

One-step mechanosynthesis of nanocrystalline oxides

One-Step Preparation of Potassium Acyltrifluoroborates

One-Step Preparation of Potassium Acyltrifluoroborates

Kussi Kussi. One-step v. Hanns Stetten

Abschnitt | Umschlag

Kussi Kussi. One-step v. Hanns Stetten

One‐Step SnO 2 Nanotree Growth

One‐Step SnO 2 Nanotree Growth

One-step synthesis of carbon-supported electrocatalysts

One-step synthesis of carbon-supported electrocatalysts

One-step synthesis of dimethyl ether using microreactors

Hochschulschrift

One-step synthesis of dimethyl ether using microreactors

One-Step Approximations For Stochastic Functional Differential Equations

One-Step Approximations For Stochastic Functional Differential Equations

The Barbier Reaction and Related One-Step Processes

The Barbier Reaction and Related One-Step Processes

CLICK: one-step generation of conditional knockout mice

CLICK: one-step generation of conditional knockout mice

Enzymatic one-step ring contraction for quinolone biosynthesis

Enzymatic one-step ring contraction for quinolone biosynthesis

One-step processes for in situ transesterification to biodiesel and lutein extraction from microalgae Phaeodactylum using instant controlled pressure drop (DIC)

One-step processes for in situ transesterification to biodiesel and lutein extraction from microalgae Phaeodactylum using instant controlled pressure drop (DIC)

Verbundene Objekte