Recent Advances in the Synthesis of Bioactive Glycohybrids via Click-Chemistry

Carbohydrates, traditionally known for their energy-providing role, have gained significant attention in drug discovery due to their diverse bioactivities and stereodiversity. However, pure carbohydrate molecules often exhibit limited bioactivity and suboptimal chemical and physical characteristics. To address these challenges, functional groups with bioactive scaffolds have been incorporated into carbohydrate to enhance their bioactivity and improve their overall properties. Among the various synthetic methods available, click chemistry has emerged as a powerful tool for the synthesis of carbohydrate-containing bioactive scaffolds, known as glycohybrids. Click chemistry offers several advantages, including high chemo- and regioselectivity, mild reaction conditions, easy purification, and compatibility with multiple functional groups. In the present review, we have emphasized the recent advances and most pertinent research on the development of 1,2,3-triazole-containing glycohybrids using the click reaction, their biological evaluations and the structure-activity relationship during 20172023. These newly synthesised glycohybrids could potentially be developed as new chemical entities (NCE) in pharmaceutical chemistry and may encourage the use of carbohydrates in drug discovery processes. 1 Introduction 2 CuAAC Click Chemistry Mediated Synthesis of Triazole-Based Glycohybrids and their Biological Activities 3 Conclusions and Perspective

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Recent Advances in the Synthesis of Bioactive Glycohybrids via Click-Chemistry ; volume:07 ; number:03 ; year:2023 ; pages:322-352 ; SynOpen ; 07, Heft 03 (2023), 322-352

Contributors, Places and Time

• Contributor: Singh, Kavita ; Tyagi, Rajdeep ; Mishra, Vinay Kumar ; Tiwari, Ghanshyam ; Sagar, Ram

Further information

• DOI: 10.1055/a-2130-7319
• URN: urn:nbn:de:101:1-2023092810414427268096
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:48 AM CEST