Innate Host Defense against Klebsiella pneumoniae and the Outlook for Development of Immunotherapies
Klebsiella pneumoniae (K. pneumoniae) is a Gram-negative commensal bacterium and opportunistic pathogen. In healthy individuals, the innate immune system is adept at protecting against K. pneumoniae infection. Notably, the serum complement system and phagocytic leukocytes (e.g., neutrophils) are highly effective at eliminating K. pneumoniae and thereby preventing severe disease. On the other hand, the microbe is a major cause of healthcare-associated infections, especially in individuals with underlying susceptibility factors, such as pre-existing severe illness or immune suppression. The burden of K. pneumoniae infections in hospitals is compounded by antibiotic resistance. Treatment of these infections is often difficult largely because the microbes are usually resistant to multiple antibiotics (multidrug resistant [MDR]). There are a limited number of treatment options for these infections and new therapies, and preventative measures are needed. Here, we review host defense against K. pneumoniae and discuss recent therapeutic measures and vaccine approaches directed to treat and prevent severe disease caused by MDR K. pneumoniae.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Innate Host Defense against Klebsiella pneumoniae and the Outlook for Development of Immunotherapies ; volume:14 ; number:3 ; year:2021 ; pages:167-181 ; extent:15
Journal of innate immunity ; 14, Heft 3 (2021), 167-181 (gesamt 15)
- Creator
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Opoku-Temeng, Clement
Malachowa, Natalia
Kobayashi, Scott D.
DeLeo, Frank R.
- DOI
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10.1159/000518679
- URN
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urn:nbn:de:101:1-2022051201153979459536
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Opoku-Temeng, Clement
- Malachowa, Natalia
- Kobayashi, Scott D.
- DeLeo, Frank R.
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