Alpha-ketoglutarate partially alleviates effects of high-fat high-fructose diet in mouse muscle

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Abstract: Consumption of high-calorie diets leads to excessive accumulation of storage lipids in adipose tissue. Metabolic changes occur not only in adipose tissue but in other tissues, too, such as liver, heart, muscle, and brain. This study aimed to explore the effects of high-fat high-fructose diet (HFFD) alone and in the combination with alpha-ketoglutarate (AKG), a well-known cellular metabolite, on energy metabolism in the skeletal muscle of C57BL/6J mice. Five-month-old male mice were divided into four groups – the control one fed a standard diet (10 % kcal fat), HFFD group fed a high-fat high-fructose diet (45 % kcal fat, 15 % kcal fructose), AKG group fed a standard diet with 1 % sodium AKG in drinking water, and HFFD + AKG group fed HFFD and water with 1 % sodium AKG. The dietary regimens lasted 8 weeks. Mice fed HFFD had higher levels of storage triacylglycerides, lower levels of glycogen, and total water-soluble protein, and higher activities of key glycolytic enzymes, namely hex.... https://www.excli.de/excli/article/view/6608

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Alpha-ketoglutarate partially alleviates effects of high-fat high-fructose diet in mouse muscle ; volume:22 ; year:2023
EXCLI journal ; 22 (2023)

Creator: Vatashchuk, Myroslava V.
Bayliak, Maria M.
Hurza, Viktoriia V.
Demianchuk, Oleh I.
Gospodaryov, Dmytro V.
Lushchak, Volodymyr I.

DOI: 10.17179/excli2023-6608

URN: urn:nbn:de:101:1-2501170216546.872176409554

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:30 AM CEST

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Vatashchuk, Myroslava V.
Bayliak, Maria M.
Hurza, Viktoriia V.
Demianchuk, Oleh I.
Gospodaryov, Dmytro V.
Lushchak, Volodymyr I.

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Alpha-ketoglutarate partially alleviates effects of high-fat high-fructose diet in mouse muscle

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Other Objects (12)

High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

Gut microbiota and mycobiota change with feeding duration in mice on a high-fat and high-fructose diet

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Cytokine modulation by etanercept ameliorates metabolic syndrome and its related complications induced in rats administered a high-fat high-fructose diet

Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats

Changes in brown adipose tissue induced by resveratrol and its analogue pterostilbene in rats fed with a high-fat high-fructose diet

Fenofibrate alleviates the composition and metabolic pathways of gut microbiota in high-fat diet treated hamsters

Study on administration of 1,5-anhydro-D-fructose in C57BL/6J mice challenged with high-fat diet

Long-term feeding of high-fat plus high-fructose diet induces isolated impaired glucose tolerance and skeletal muscle insulin resistance in miniature pigs

Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease

Hoxa5 alleviates adipose tissue metabolic distortions in high-fat diet mice associated with a reduction in MERC

Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet

High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

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Changes in brown adipose tissue induced by resveratrol and its analogue pterostilbene in rats fed with a high-fat high-fructose diet

Fenofibrate alleviates the composition and metabolic pathways of gut microbiota in high-fat diet treated hamsters

Study on administration of 1,5-anhydro-D-fructose in C57BL/6J mice challenged with high-fat diet

Long-term feeding of high-fat plus high-fructose diet induces isolated impaired glucose tolerance and skeletal muscle insulin resistance in miniature pigs

Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease

Hoxa5 alleviates adipose tissue metabolic distortions in high-fat diet mice associated with a reduction in MERC

Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet

High-fructose and high-fat diet-induced disorders in rats: impact on diabetes risk, hepatic and vascular complications

Gut microbiota and mycobiota change with feeding duration in mice on a high-fat and high-fructose diet

CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype

Cytokine modulation by etanercept ameliorates metabolic syndrome and its related complications induced in rats administered a high-fat high-fructose diet

Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats

Changes in brown adipose tissue induced by resveratrol and its analogue pterostilbene in rats fed with a high-fat high-fructose diet

Fenofibrate alleviates the composition and metabolic pathways of gut microbiota in high-fat diet treated hamsters

Study on administration of 1,5-anhydro-D-fructose in C57BL/6J mice challenged with high-fat diet

Long-term feeding of high-fat plus high-fructose diet induces isolated impaired glucose tolerance and skeletal muscle insulin resistance in miniature pigs

Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease

Hoxa5 alleviates adipose tissue metabolic distortions in high-fat diet mice associated with a reduction in MERC

Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet

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