Alpha-ketoglutarate partially alleviates effects of high-fat high-fructose diet in mouse muscle

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Abstract: Consumption of high-calorie diets leads to excessive accumulation of storage lipids in adipose tissue. Metabolic changes occur not only in adipose tissue but in other tissues, too, such as liver, heart, muscle, and brain. This study aimed to explore the effects of high-fat high-fructose diet (HFFD) alone and in the combination with alpha-ketoglutarate (AKG), a well-known cellular metabolite, on energy metabolism in the skeletal muscle of C57BL/6J mice. Five-month-old male mice were divided into four groups – the control one fed a standard diet (10 % kcal fat), HFFD group fed a high-fat high-fructose diet (45 % kcal fat, 15 % kcal fructose), AKG group fed a standard diet with 1 % sodium AKG in drinking water, and HFFD + AKG group fed HFFD and water with 1 % sodium AKG. The dietary regimens lasted 8 weeks. Mice fed HFFD had higher levels of storage triacylglycerides, lower levels of glycogen, and total water-soluble protein, and higher activities of key glycolytic enzymes, namely hex.... https://www.excli.de/excli/article/view/6608

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Alpha-ketoglutarate partially alleviates effects of high-fat high-fructose diet in mouse muscle ; volume:22 ; year:2023
EXCLI journal ; 22 (2023)

Urheber
Vatashchuk, Myroslava V.
Bayliak, Maria M.
Hurza, Viktoriia V.
Demianchuk, Oleh I.
Gospodaryov, Dmytro V.
Lushchak, Volodymyr I.

DOI
10.17179/excli2023-6608
URN
urn:nbn:de:101:1-2501170216546.872176409554
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:30 MESZ

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Beteiligte

  • Vatashchuk, Myroslava V.
  • Bayliak, Maria M.
  • Hurza, Viktoriia V.
  • Demianchuk, Oleh I.
  • Gospodaryov, Dmytro V.
  • Lushchak, Volodymyr I.

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