Insulin Glargine is more suitable than Exenatide to prevent muscle loss in non-obese type 2 diabetic patients with NAFLD

Abstract Aim: The aim of this study was to investigate the effects of Insulin Glargine and Exenatide on the muscle mass of patients with newly diagnosed type 2 diabetes (T2DM) and nonalcoholic fatty liver disease (NAFLD). Methods: We performed a post-hoc analysis of our previously study, a 24-week randomized controlled multicenter clinical trial (ClinicalTrials.gov, NCT02303730). Seventy-six patients were randomly assigned 1:1 to receive Insulin Glargine or Exenatide treatment. The changes in psoas muscle area (PMA) (mm2) was obtained with the cross-sectional Dixonfat magnetic resonance images at the fourth lumber veterbra. Results: There were no significant differences in age, BMI, gender, and PMA in Insulin Glargine and Exenatide group at baseline. After treatment, PMA tended to increase by 13.13 (-215.52, 280.80) mm2 in Insulin Glargine group and decrease by 149.09 (322.90,-56.39) mm2 in Exenatide group (both p >0.05). Subgroup analysis showed a 560.64 (77.88, 1043.40) (mm2) increase of PMA in Insulin group relative to Exenatide group in patients with BMI < 28kg/m2 (p = 0.031), after adjusting for gender, age and research center. Interaction analysis showed an interaction between BMI and treatment (p = 0.009). However, no interaction was observed among subgroups with a BMI ≥ 28kg/m2 or with different genders and ages. Conclusion: Compared to the Exenatide, Insulin Glargine can relativity increase PMA in T2DM patients with BMI< 28 kg/m2 and NAFLD.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Insulin Glargine is more suitable than Exenatide to prevent muscle loss in non-obese type 2 diabetic patients with NAFLD ; day:31 ; month:07 ; year:2023 ; Experimental and clinical endocrinology & diabetes ; (31.07.2023)

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: liu, lin ; gao, jian ; wang, ruwen ; yan, jinghua ; zhang, jingtian ; lin, huandong ; rao, shengxiang ; yao, xiuzhong ; wu, weiyun ; hua, bian ; zhang, zhitian ; Liu, Jiaojiao ; guo, shanshan ; gao, xin ; yan, hongmei

Weitere Informationen

• DOI: 10.1055/a-2145-1004
• URN: urn:nbn:de:101:1-2023091411023616867056
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:57 MESZ