Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

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Abstract: Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola‐amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola‐amphiphilic feature enabled stronger binding to lectin compared to conventional amphiphiles. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, thus allowing effective and specific cellular uptake. This highlights their great promise for targeted delivery.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins ; day:26 ; month:08 ; year:2022 ; extent:1
Chemistry - a European journal ; (26.08.2022) (gesamt 1)

Creator
Zhang, Wenzheng
Dhumal, Dinesh
Zhu, Xiaolei
Ralahy, Brigino
Ellert‐Miklaszewska, Aleksandra
Wu, Jing
Laurini, Erik
Yao, Yi‐Wen
Kao, Chai‐Lin
Iovanna, Juan L.
Pricl, Sabrina
Kaminska, Bozena
Xia, Yi
Peng, Ling

DOI
10.1002/chem.202201400
URN
urn:nbn:de:101:1-2022083015051539753850
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:24 AM CEST

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Associated

  • Zhang, Wenzheng
  • Dhumal, Dinesh
  • Zhu, Xiaolei
  • Ralahy, Brigino
  • Ellert‐Miklaszewska, Aleksandra
  • Wu, Jing
  • Laurini, Erik
  • Yao, Yi‐Wen
  • Kao, Chai‐Lin
  • Iovanna, Juan L.
  • Pricl, Sabrina
  • Kaminska, Bozena
  • Xia, Yi
  • Peng, Ling

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