The under‐appreciated world of the serpin family of serine proteinase inhibitors
In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors that, in turn, regulate these proteases. The serpins are a family of proteins with a shared tertiary structure, whose members largely act as serine protease inhibitors, found in all forms of life, ranging from viruses, bacteria, and archaea to plants and animals. These proteins represent up to 2–10% of proteins in the human blood and are the third most common protein family.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The under‐appreciated world of the serpin family of serine proteinase inhibitors ; day:09 ; month:05 ; year:2023 ; extent:5
EMBO molecular medicine / European Molecular Biology Organization ; (09.05.2023) (gesamt 5)
- Creator
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Bouton, Marie‐Christine
Geiger, Margarethe
Sheffield, William P.
Irving, James A.
Lomas, David A.
Song, Sihong
Satyanarayanan, Ritvik S.
Zhang, Liqiang
McFadden, Grant
Lucas, Alexandra R.
- DOI
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10.15252/emmm.202217144
- URN
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urn:nbn:de:101:1-2023050917014409670584
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:52 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Bouton, Marie‐Christine
- Geiger, Margarethe
- Sheffield, William P.
- Irving, James A.
- Lomas, David A.
- Song, Sihong
- Satyanarayanan, Ritvik S.
- Zhang, Liqiang
- McFadden, Grant
- Lucas, Alexandra R.
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Gene expression of serine and cysteine proteinase inhibitors during cereal leaf beetle larvae feeding on wheat: the role of insect-associated microorganisms
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Molecular characterization of a Trichinella spiralis serine proteinase
Structural studies of the serine-carboxyl proteinase kumamolisin and the metallopeptidase peptidyl-dipeptidase Dcp
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An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica
Gene expression of serine and cysteine proteinase inhibitors during cereal leaf beetle larvae feeding on wheat: the role of insect-associated microorganisms
Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide–PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer
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