Nucleic Acid Templated Reactions for Chemical Biology
Abstract: Nucleic acid directed bioorthogonal reactions offer the fascinating opportunity to unveil and redirect a plethora of intracellular mechanisms. Nano‐ to picomolar amounts of specific RNA molecules serve as templates and catalyze the selective formation of molecules that 1) exert biological effects, or 2) provide measurable signals for RNA detection. Turnover of reactants on the template is a valuable asset when concentrations of RNA templates are low. The idea is to use RNA‐templated reactions to fully control the biodistribution of drugs and to push the detection limits of DNA or RNA analytes to extraordinary sensitivities. Herein we review recent and instructive examples of conditional synthesis or release of compounds for in cellulo protein interference and intracellular nucleic acid imaging.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Nucleic Acid Templated Reactions for Chemical Biology ; volume:12 ; number:12 ; year:2017 ; pages:872-882 ; extent:11
ChemMedChem ; 12, Heft 12 (2017), 872-882 (gesamt 11)
- Creator
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Di Pisa, Margherita
Seitz, Oliver
- DOI
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10.1002/cmdc.201700266
- URN
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urn:nbn:de:101:1-2022092705540306136874
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Di Pisa, Margherita
- Seitz, Oliver
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