High expression of XIAP and Bcl-2 may inhibit programmed cell death in glioblastomas
Abstract: Glioblastoma (GBM) is the most malignant glioma and represents 29% of all brain tumors. Tumorigenesis is intimately connected with characteristics acquired in the physiologic pathway of cellular death. Objective: In the present study, the expression of anti-apoptotic (XIAP and Bcl-2) and apoptotic (cytochrome C, caspase 9, APAF-1), caspase 3 and the Smac/DIABLO genes related to the apoptosis pathway were evaluated in 30 samples of glioblastoma. Methods: The gene expression was evaluated in 30 glioblastomas (WHO grade IV) and compared to 10 white matter control samples with real-time PCR. Results and Conclusion: There were higher expressions of XIAP (p = 0.0032) and Bcl-2 (p = 0.0351) in the glioblastoma samples compared to the control samples of normal brain. These results raise the question of whether Bcl-2 and XIAP genes can be responsible for the inhibition of programmed cell death in glioblastomas. Moreover, they provide additional information capable of allowing the development of new target therapy strategies.
- Alternative title
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Alta expressão de XIAP e Bcl-2 pode inibir morte celular programada em glioblastomas
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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High expression of XIAP and Bcl-2 may inhibit programmed cell death in glioblastomas ; volume:75 ; number:12 ; year:2017 ; pages:875-880
Arquivos de neuro-psiquiatria ; 75, Heft 12 (2017), 875-880
- Contributor
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Tirapelli, Daniela Pretti da Cunha
Lustosa, Isis Lacrose
Menezes, Sarah Bomfim
Franco, Indira Maynart
Rodrigues, Andressa Romualdo
Peria, Fernanda Maris
Marinho, Alexandre Magno da Nóbrega
Serafini, Luciano Neder
Carlotti, Carlos Gilberto
Tirapelli, Luís Fernando
- DOI
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10.1590/0004-282X20170156
- URN
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urn:nbn:de:101:1-2023101910202084625521
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:02 AM CEST
Data provider
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Associated
- Tirapelli, Daniela Pretti da Cunha
- Lustosa, Isis Lacrose
- Menezes, Sarah Bomfim
- Franco, Indira Maynart
- Rodrigues, Andressa Romualdo
- Peria, Fernanda Maris
- Marinho, Alexandre Magno da Nóbrega
- Serafini, Luciano Neder
- Carlotti, Carlos Gilberto
- Tirapelli, Luís Fernando
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Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis
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Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain
Somatic retrotransposition is infrequent in glioblastomas
Röntgenstrukturanalyse der Caspase-3-XIAP-BIR2-, Caspase-7-XIAP-BIR2-Komplexe und der Procaspase-7
Röntgenstrukturanalyse der Caspase-3-XIAP-BIR2, Caspase-7-XIAP-BIR2-Komplexe und der Procaspase-7
SMAC dependency of XIAP mediated chemoresistance
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Bevacizumab for patients with recurrent multifocal glioblastomas
Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis
Small interfering RNA-vermittelte Hemmung der Apoptoseinhibitoren BCL2, BCL-XL, XIAP und Survivin in Zellkultur- und Mausmodellen des humanen Harnblasenkarzinoms
Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain
Somatic retrotransposition is infrequent in glioblastomas
Röntgenstrukturanalyse der Caspase-3-XIAP-BIR2-, Caspase-7-XIAP-BIR2-Komplexe und der Procaspase-7
Röntgenstrukturanalyse der Caspase-3-XIAP-BIR2, Caspase-7-XIAP-BIR2-Komplexe und der Procaspase-7
SMAC dependency of XIAP mediated chemoresistance
SMAC dependency of XIAP mediated chemoresistance
XIAP Confers Immunity Against Intracellular Bacteria
Epigallocatechin gallate and curcumin inhibit Bcl-2: a pharmacophore and docking based approach against cancer
Transduktion axotomierter, retinaler Ganglienzellen der Ratte durch rekombinante adenovirale Vektoren mit Transgenen für XIAP und Bcl-XL erhöht die Anzahl überlebender Ganglienzellen