Host-response biomarkers for the diagnosis of bacterial respiratory tract infections
Abstract: Appropriate antibiotic treatment for respiratory tract infections (RTIs) necessitates rapid and accurate diagnosis of microbial etiology, which remains challenging despite recent innovations. Several host response-based biomarkers due to infection have been suggested to allow discrimination of bacterial and non-bacterial microbial RTI etiology. This review provides an overview of clinical studies that investigated the diagnostic performance of host-response proteomic biomarkers to identify RTI microbial etiology. Procalcitonin and C-reactive protein have been studied most extensively; whereof procalcitonin has demonstrated the strongest diagnostic performance compared to other biomarkers. Proadrenomedullin, soluble triggering receptor expressed on myeloid cells-1, neopterin and pentraxin-3 need more studies to confirm their diagnostic value. For syndecan-4 and lipocalin-2 currently insufficient evidence exists. Common limitations in several of the studies were the relatively small scale setting, heterogeneous patient population and the absence of statistical power calculation.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Host-response biomarkers for the diagnosis of bacterial respiratory tract infections ; volume:57 ; number:4 ; year:2019 ; pages:442-451 ; extent:10
Clinical chemistry and laboratory medicine ; 57, Heft 4 (2019), 442-451 (gesamt 10)
- Creator
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Saleh, Mohammed A.A.
van de Garde, Ewoudt M.W.
van Hasselt, J.G. Coen
- DOI
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10.1515/cclm-2018-0682
- URN
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urn:nbn:de:101:1-2022060216445165099517
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Saleh, Mohammed A.A.
- van de Garde, Ewoudt M.W.
- van Hasselt, J.G. Coen
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