Copper‐Catalyzed Addition of Grignard Reagents to in situ Generated Indole‐Derived Vinylogous Imines
Abstract: Chiral indole derivatives are ubiquitous motifs in pharmaceuticals and alkaloids. Herein, the first protocol for catalytic asymmetric conjugate addition of Grignard reagents to various sulfonyl indoles, offering a straightforward approach for the synthesis of chiral 3‐sec‐alkyl‐substituted indoles in high yields and enantiomeric ratios is presented. This methodology makes use of a chiral catalyst based on copper phosphoramidite complexes and in situ formation of vinylogous imine intermediates.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Copper‐Catalyzed Addition of Grignard Reagents to in situ Generated Indole‐Derived Vinylogous Imines ; volume:26 ; number:69 ; year:2020 ; pages:16277-16280 ; extent:4
Chemistry - a European journal ; 26, Heft 69 (2020), 16277-16280 (gesamt 4)
- Creator
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Ge, Luo
Zurro, Mercedes
Harutyunyan, Syuzanna R.
- DOI
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10.1002/chem.202004232
- URN
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urn:nbn:de:101:1-2022060712581557532208
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:36 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Ge, Luo
- Zurro, Mercedes
- Harutyunyan, Syuzanna R.
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Low-Temperature Cross-Coupling of Functionalized Grignard Reagents
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Low-Temperature Cross-Coupling of Functionalized Grignard Reagents
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