Journal article | Zeitschriftenartikel
Differences in hypothalamic–pituitary–adrenal axis functioning among children with ADHD predominantly inattentive and combined types
Some evidence suggests that the HPA axis may be dysfunctional in children with attention-deficit/ hyperactivity disorder (ADHD). The aim of this study was to investigate whether a different pattern of HPA axis activity is found between the inattentive (I) and combined (C) subtypes of ADHD, in comparison with healthy control children. A total of 100 prepubertal subjects [52 children with ADHD combined type (ADHD-C), 23 children with ADHD predominantly inattentive type (ADHD-I), and 25 healthy control subjects] were studied. The effects of stress were studied by comparing cortisol responses to a psychosocial stressor, consisting of a public speaking task. Children with ADHD-I showed an elevated cortisol response to the psychosocial stressor, in contrast to children with ADHD-C who showed a blunted cortisol response to the psychosocial stressor. When a distinction was made between responders and non-responders (a subject was classified as a responder when there was an increase in cortisol reactivity), hyperactivity symptoms were clearly related to a lower cortisol reactivity to stress. The results indicate that a low-cortisol responsivity to stress may be a neurobiological marker for children with ADHD-C, but not for those with ADHD-I. Directions for future research and clinical implications are discussed.
- Extent
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Seite(n): 543-553
- Language
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Englisch
- Notes
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Status: Postprint; begutachtet (peer reviewed)
- Bibliographic citation
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European Child & Adolescent Psychiatry, 18(9)
- Subject
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Psychologie
psychische Störungen, Behandlung und Prävention
Stress
- Event
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Geistige Schöpfung
- (who)
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West, Dirk
Claes, Stephan
Deboutte, Dirk
- Event
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Veröffentlichung
- (where)
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Deutschland
- (when)
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2009
- DOI
- URN
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urn:nbn:de:0168-ssoar-202684
- Rights
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GESIS - Leibniz-Institut für Sozialwissenschaften. Bibliothek Köln
- Last update
-
21.06.2024, 4:27 PM CEST
Data provider
GESIS - Leibniz-Institut für Sozialwissenschaften. Bibliothek Köln. If you have any questions about the object, please contact the data provider.
Object type
- Zeitschriftenartikel
Associated
- West, Dirk
- Claes, Stephan
- Deboutte, Dirk
Time of origin
- 2009
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Activation of the hypothalamic-pituitary adrenal axis in response to a verbal fluency task and associations with task performance
Differences in hypothalamic–pituitary–adrenal axis functioning among children with ADHD predominantly inattentive and combined types
Multiple sclerosis related fatigue and the hypothalamic pituitary adrenal axis
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Identification of SPRED2 as a Novel Regulator of Hypothalamic-Pituitary-Adrenal Axis Activity and of Body Homeostasis
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Effects of dexamethasone and training on the hypothalamic-pituitary-adrenal response on mild stress challenge in dairy cows
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