Bladder cancer course, four genetic high-risk variants, and histopathological findings
Abstract: Urinary bladder cancer, a smoking and occupation related disease, was subject of several genome-wide association studies (GWAS). However, studies on the course of the disease based on GWAS findings differentiating between muscle invasive bladder cancer (MIBC) and non-muscle invasive bladder cancer (NMIBC) are rare. Thus we investigated 4 single nucleotide polymorphisms (SNPs) detected in GWAS, related to the genes coding for TACC3 (transforming, acidic coiled-coil containing protein 3), for FGFR3 (fibroblast growth factor receptor 3), for PSCA (prostate stem cell antigen) and the genes coding for CBX6 (chromobox homolog 6) and APOBEC3A (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A). This study is based on 712 bladder cancer patients and 875 controls from 3 different case control studies in Germany. The 4 SNPs of interest (PSCA rs2294008 and rs2978974, FGFR3-TACC3 rs798766, and CBX6-APOBEC3A rs1014971) were determined by real-time polymerase chain reaction. Th.... https://www.excli.de/index.php/excli/article/view/5862
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Bladder cancer course, four genetic high-risk variants, and histopathological findings ; volume:22 ; year:2023
EXCLI journal ; 22 (2023)
- Urheber
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Kadhum, Thura
Selinski, Silvia
Blaszkewicz, Meinolf
Reinders, Jörg
Roth, Emanuel
Volkert, Frank
Ovsiannikov, Daniel
Moormann, Oliver
Gerullis, Holger
Barski, Dimitri
Otto, Thomas
Höhne, Svetlana
Hengstler, Jan G.
Golka, Klaus
- DOI
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10.17179/excli2023-5862
- URN
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urn:nbn:de:101:1-2023090803141205211593
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:52 MESZ
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Beteiligte
- Kadhum, Thura
- Selinski, Silvia
- Blaszkewicz, Meinolf
- Reinders, Jörg
- Roth, Emanuel
- Volkert, Frank
- Ovsiannikov, Daniel
- Moormann, Oliver
- Gerullis, Holger
- Barski, Dimitri
- Otto, Thomas
- Höhne, Svetlana
- Hengstler, Jan G.
- Golka, Klaus
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