Molecular Encapsulation Inside Microtubules Based on Tau‐Derived Peptides
Abstract: Microtubules are cytoskeletal filaments that serve as attractive scaffolds for developing nanomaterials and nanodevices because of their unique structural properties. The functionalization of the outer surface of microtubules has been established for this purpose. However, no attempts have been made to encapsulate molecules inside microtubules with 15 nm inner diameter. The encapsulation of various molecular cargos inside microtubules constitutes a new concept for nanodevice and nanocarrier applications of microtubules. Here, we developed peptide motifs for binding to the inner surface of microtubules, based on a repeat domain of the microtubule‐associated protein Tau. One of the four Tau‐derived peptides, 2N, binds to a taxol binding pocket of β‐tubulin located inside microtubules by preincubation with tubulin dimer and subsequent polymerization of the peptide‐tubulin complex. By conjugation of 2N to gold nanoparticles, encapsulation of gold nanoparticles inside microtubules was achieved. The methodology for molecular encapsulation inside microtubules by the Tau‐derived peptide is expected to advance the development of microtubule‐based nanomaterials and nanodevices.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Molecular Encapsulation Inside Microtubules Based on Tau‐Derived Peptides ; volume:24 ; number:56 ; year:2018 ; pages:14958-14967 ; extent:10
Chemistry - a European journal ; 24, Heft 56 (2018), 14958-14967 (gesamt 10)
- Creator
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Inaba, Hiroshi
Yamamoto, Takahisa
Kabir, Arif Md. Rashedul
Kakugo, Akira
Sada, Kazuki
Matsuura, Kazunori
- DOI
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10.1002/chem.201802617
- URN
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urn:nbn:de:101:1-2022082105570078347185
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:20 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Inaba, Hiroshi
- Yamamoto, Takahisa
- Kabir, Arif Md. Rashedul
- Kakugo, Akira
- Sada, Kazuki
- Matsuura, Kazunori
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