Dynamic organization of the mitochondrial protein import machinery
Abstract: Mitochondria contain elaborate machineries for the import of precursor proteins from the cytosol. The translocase of the outer mitochondrial membrane (TOM) performs the initial import of precursor proteins and transfers the precursors to downstream translocases, including the presequence translocase and the carrier translocase of the inner membrane, the mitochondrial import and assembly machinery of the intermembrane space, and the sorting and assembly machinery of the outer membrane. Although the protein translocases can function as separate entities in vitro, recent studies revealed a close and dynamic cooperation of the protein import machineries to facilitate efficient transfer of precursor proteins in vivo. In addition, protein translocases were found to transiently interact with distinct machineries that function in the respiratory chain or in the maintenance of mitochondrial membrane architecture. Mitochondrial protein import is embedded in a regulatory network that ensures protein biogenesis, membrane dynamics, bioenergetic activity and quality control.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Dynamic organization of the mitochondrial protein import machinery ; volume:397 ; number:11 ; year:2016 ; pages:1097-1114 ; extent:18
Biological chemistry ; 397, Heft 11 (2016), 1097-1114 (gesamt 18)
- Creator
- DOI
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10.1515/hsz-2016-0145
- URN
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urn:nbn:de:101:1-2408051751238.087535180340
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:51 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Straub, Sebastian P.
- Stiller, Sebastian B.
- Wiedemann, Nils
- Pfanner, Nikolaus
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