The awesome lysosome
In the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell's “suicide bag” (de Duve, 2005). Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer. Over 50 different types of lysosomal storage diseases have been identified, each due to the deficiency or malfunction of a specific lysosomal protein. In addition, an important role of the lysosome has been unveiled in several common human diseases, such as cancer, obesity, neurodegenerative diseases, and infection. Recent studies have led to the identification of a lysosome‐to‐nucleus signaling pathway and a lysosomal gene network that regulate cellular clearance and energy metabolism. These observations have opened a completely new field of research and changed our traditional view of the lysosome from a dead‐end organelle to a control center of cell metabolism. An important challenge for the future will be to exploit these discoveries to identify modulators of lysosomal function that may be used to treat human diseases.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
The awesome lysosome ; volume:8 ; number:2 ; year:2016 ; pages:73-76 ; extent:4
EMBO molecular medicine / European Molecular Biology Organization ; 8, Heft 2 (2016), 73-76 (gesamt 4)
- Creator
- DOI
-
10.15252/emmm.201505966
- URN
-
urn:nbn:de:101:1-2022111405110748390009
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:37 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Other Objects (12)
Lysosome biogenesis during osteoclastogenesis
Extracellular protein degradation via the lysosome
TECPR1 helps bridge the CASM during lysosome damage
Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
The IAP family member BRUCE regulates autophagosome–lysosome fusion
Atg5 regulates late endosome and lysosome biogenesis
Lysosome function in glomerular health and disease
Emerging new roles of the lysosome and neuronal ceroid lipofuscinoses
TFEB ‐dependent lysosome biogenesis is required for senescence
Keratinocyte differentiation promotes ER stress-dependent lysosome biogenesis
Lysosome quality control in health and neurodegenerative diseases
Lysosome‐Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy
Lysosome biogenesis during osteoclastogenesis
Extracellular protein degradation via the lysosome
TECPR1 helps bridge the CASM during lysosome damage
Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
The IAP family member BRUCE regulates autophagosome–lysosome fusion
Atg5 regulates late endosome and lysosome biogenesis
Lysosome function in glomerular health and disease
Emerging new roles of the lysosome and neuronal ceroid lipofuscinoses
TFEB ‐dependent lysosome biogenesis is required for senescence
Keratinocyte differentiation promotes ER stress-dependent lysosome biogenesis
Lysosome quality control in health and neurodegenerative diseases
Lysosome‐Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy
Lysosome biogenesis during osteoclastogenesis
Extracellular protein degradation via the lysosome
TECPR1 helps bridge the CASM during lysosome damage
Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria
The IAP family member BRUCE regulates autophagosome–lysosome fusion
Atg5 regulates late endosome and lysosome biogenesis
Lysosome function in glomerular health and disease
Emerging new roles of the lysosome and neuronal ceroid lipofuscinoses
TFEB ‐dependent lysosome biogenesis is required for senescence
Keratinocyte differentiation promotes ER stress-dependent lysosome biogenesis
Lysosome quality control in health and neurodegenerative diseases