Therapeutic strategies for primary heart involvement in systemic sclerosis

Abstract: Primary heart involvement (pHI) is frequent in systemic sclerosis (SSc), even though often underdiagnosed. SSc-pHI has been recently defined as cardiac abnormalities that are predominantly attributable to SSc rather than other causes and/or complications. SSc-pHI represents a major determinant of mortality in SSc, accounting alone for about 12% of disease-related deaths; its early recognition and promptly therapeutic interventions are therefore crucial. Both perfusion defects and myocardial inflammation contribute to the occurrence of myocardial fibrosis that precipitates myocardial remodeling, potentially leading to heart failure and arrhythmic complications. To date, clear evidence and guidelines for effectively managing SSc pHI are not established yet, resulting in a lack of a defined therapeutic algorithm. In this review we summarize the most recent scientific literature on the prevailing therapeutic strategies and interventions to manage SSc-pHI, with particular focus on therapeutic strategies to counteract the 3 major pathogenic events of the disease, i.e. microvascular damage, myocardial inflammation and myocardial fibrosis.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Therapeutic strategies for primary heart involvement in systemic sclerosis ; volume:5 ; number:2 ; year:2024 ; pages:72-82 ; extent:11 ; Rheumatology and immunology research ; 5, Heft 2 (2024), 72-82 (gesamt 11)

Contributors, Places and Time

• Creator: Batani, Veronica ; Dagna, Lorenzo ; De Luca, Giacomo

Further information

• DOI: 10.1515/rir-2024-0010
• URN: urn:nbn:de:101:1-2407151542562.196338678015
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:57 AM CEST