Synthetic Silica Nano‐Organelles for Regulation of Cascade Reactions in Multi‐Compartmentalized Systems

Abstract: In eukaryotic cells, enzymes are compartmentalized into specific organelles so that different reactions and processes can be performed efficiently and with a high degree of control. In this work, we show that these features can be artificially emulated in robust synthetic organelles constructed using an enzyme co‐compartmentalization strategy. We describe an in situ encapsulation approach that allows enzymes to be loaded into silica nanoreactors in well‐defined compositions. The nanoreactors can be combined into integrated systems to produce a desired reaction outcome. We used the selective enzyme co‐compartmentalization and nanoreactor integration to regulate competitive cascade reactions and to modulate the kinetics of sequential reactions involving multiple nanoreactors. Furthermore, we show that the nanoreactors can be efficiently loaded into giant polymer vesicles, resulting in multi‐compartmentalized microreactors.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Synthetic Silica Nano‐Organelles for Regulation of Cascade Reactions in Multi‐Compartmentalized Systems ; day:27 ; month:12 ; year:2021 ; extent:7 ; Angewandte Chemie ; (27.12.2021) (gesamt 7)

Contributors, Places and Time

• Creator: Jiang, Shuai ; Caire da Silva, Lucas ; Ivanov, Tsvetomir ; Mottola, Milagro ; Landfester, Katharina

Further information

• DOI: 10.1002/ange.202113784
• URN: urn:nbn:de:101:1-2021122814120157445049
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:33 AM CEST