Mesoscale Clusters in the Crystallisation of Organic Molecules

Abstract: The early stages of the molecular self‐assembly pathway leading to crystal nucleation have a significant influence on the properties and purity of organic materials. This mini review collates the work on organic mesoscale clusters and discusses their importance in nucleation processes, with a particular focus on their critical properties and susceptibility to sample treatment parameters. This is accomplished by a review of detection methods, including dynamic light scattering, nanoparticle tracking analysis, small angle X‐ray scattering, and transmission electron microscopy. Considering the challenges associated with crystallisation of flexible and large‐molecule active pharmaceutical ingredients, the dynamic nature of mesoscale clusters has the potential to expand the discovery of novel crystal forms. By collating literature on mesoscale clusters for organic molecules, a more comprehensive understanding of their role in nucleation will evolve and can guide further research efforts.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Mesoscale Clusters in the Crystallisation of Organic Molecules ; day:22 ; month:12 ; year:2023 ; extent:16 ; Angewandte Chemie / International edition. International edition ; (22.12.2023) (gesamt 16)

Contributors, Places and Time

• Creator: Barua, Harsh ; Svärd, Michael ; Rasmuson, Åke C. ; Hudson, Sarah P. ; Cookman, Jennifer

Further information

• DOI: 10.1002/anie.202312100
• URN: urn:nbn:de:101:1-2023122314020323876947
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:31 AM CEST