Arbeitspapier
Robustness of optimal designs for the Michaelis-Menten model under a variation of criteria
The Michaelis-Menten model has and continues to be one of the most widely used models in many diverse fields. In the biomedical sciences, the model continues to be ubiquitous in biochemistry, enzyme kinetics studies, nutrition science and in the pharmaceutical sciences. Despite its wide ranging applications across disciplines, design issues for this model are given short shrift. This paper focuses on design issues and provides a variety of optimal designs of this model. In addition, we evaluate robustness properties of the optimal designs under a variation in optimality criteria. To facilitate use of optimal design ideas in practice, we design a web site for generating and comparing dfferent types of tailor-made optimal designs and user-supplied designs for the Michaelis-Menten and related models.
- Sprache
-
Englisch
- Erschienen in
-
Series: Technical Report ; No. 2008,23
- Thema
-
c-optimal designs
effiency
Elfving's method
extrapolation optimal design
uniform design
geometric design
- Ereignis
-
Geistige Schöpfung
- (wer)
-
Dette, Holger
Kiss , Christine
Wong, Weng Kee
- Ereignis
-
Veröffentlichung
- (wer)
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Technische Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
- (wo)
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Dortmund
- (wann)
-
2008
- Handle
- Letzte Aktualisierung
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10.03.2025, 11:42 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
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ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften - Leibniz-Informationszentrum Wirtschaft. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Objekttyp
- Arbeitspapier
Beteiligte
- Dette, Holger
- Kiss , Christine
- Wong, Weng Kee
- Technische Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen
Entstanden
- 2008
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