Gitelman’s and Bartter’s Syndromes: From Genetics to the Molecular Basis of Hypertension and More

Background: Gitelman’s and Bartter’s syndromes (GS/BS) are rare genetic tubulopathies characterized by electrolyte imbalance and activation of the renin-angiotensin-aldosterone system (RAAS). These syndromes have intriguing biochemical and hormonal abnormalities that lead them to be protected from hypertension and cardiovascular and renal remodeling. Summary: In this review, we explore the biochemical/molecular mechanisms induced by the activation of the RAAS and its counterregulatory arm which is particularly activated in GS/BS patients, in the context of blood pressure regulation. In addition, we report our findings in the context of the COVID-19 pandemic where we observed GS/BS subjects being protected from infection. Key Messages: The intracellular pathways induced by Ang II, starting from induction of oxidative stress and vasoconstriction, are crucial for the progression toward cardiovascular-renal remodeling and might be useful targets in order to reduce/halt the progression of Ang II/oxidative stress-induced cardiovascular-renal morbidity in several diseases.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Gitelman’s and Bartter’s Syndromes: From Genetics to the Molecular Basis of Hypertension and More ; volume:47 ; number:9 ; year:2022 ; pages:556-564 ; extent:9 ; Kidney & blood pressure research ; 47, Heft 9 (2022), 556-564 (gesamt 9)

Contributors, Places and Time

• Creator: Ravarotto, Verdiana ; Bertoldi, Giovanni ; Stefanelli, Lucia Federica ; Nalesso, Federico ; Calò, Lorenzo A.

Further information

• DOI: 10.1159/000526070
• URN: urn:nbn:de:101:1-2022102000171242666401
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:28 AM CEST