Oral glucose tolerance test in unstimulated saliva of healthy individuals
Abstract: Objective: The aim of this study was to investigate oral glucose tolerance test (OGTT) in unstimulated whole saliva as a diagnostic specimen in clinical practice for detection of diabetes mellitus (DM). Materials and Methods: An interventional study was carried out in 30 apparently healthy individuals aged 24-59 years. Serum and saliva samples were obtained in fasting, 1 h and 2 h after glucose intake (75 g). Glucose concentration was determined by enzymatic colorimetric glucose oxidase-prostatic acid phosphatase assay. Statistical analysis of the repeated ANOVA (followed Bonferroni post-hoc test) and Pearson correlation coefficient were used. Results: The mean serum glucose concentration was significantly higher 1 h after glucose intake (152.32 ± 31.06) than both fasting state (106.38 ± 41.08; P < 0.001) and 2 h after glucose intake (125.21 ± 51.71; P < 0.001). Saliva glucose was also significantly higher 1 h after glucose intake (5.46 ± 2.41) than both fasting state (2.84 ± 1.46; P < 0.001) and 2 h after glucose intake (4.01 ± 1.91; P < 0.001). There were significant positive correlation between saliva and serum glucose concentration in fasting state (r = 0.502; P = 0.044), 1 h (r = 0.756; P = 0.0001), and 2 h (r = 0.543; P = 0.023) after oral glucose intake. Conclusion: It seems that unstimulated saliva can be used as an alternative to serum for diagnosis of DM in OGTT.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Oral glucose tolerance test in unstimulated saliva of healthy individuals ; volume:5 ; number:01 ; year:2016 ; pages:15-18
European journal of general dentistry ; 5, Heft 01 (2016), 15-18
- Contributor
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Mirzaii-Dizgah, Mohammad-Hossein
Mirzaii-Dizgah, Iraj
Mirzaii-Dizgah, Mohammad-Reza
- DOI
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10.4103/2278-9626.172736
- URN
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urn:nbn:de:101:1-2021121611242895334205
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:22 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Mirzaii-Dizgah, Mohammad-Hossein
- Mirzaii-Dizgah, Iraj
- Mirzaii-Dizgah, Mohammad-Reza
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