Evaluation of the cytotoxic and immunogenic potential of temozolamide, panobinostat, and Lophophora williamsii extract against C6 glioma cells

Abstract: Glioblastoma multiforme is a malignant neoplasm of the brain with poor prognosis. The first-line drug against glioblastoma is the alkylating agent temozolamide (TMZ); unfortunately, treatment resistance and tumor re-incidence are common. In some cases, immunogenic cell death (ICD) inducers can decrease treatment resistance and tumor recurrence by stimulating an antitumor specific immune response. Not all ICD inducers, however, are suitable for glioma patients because of the low permeability of the blood-brain barrier (BBB). Panobinostat (PAN), a histone deacetylase inhibitor and Lophophora williamsii (LW) extract can pass through the BBB and have antitumor properties. The aim of this study is to evaluate the cytotoxic potential of TMZ, PAN and LW extract against the glioma C6 cell line, and its role in the release of damage-associated molecular patterns (DAMPs), which is a hallmark of ICD. Our results indicate that all treatments induce cellular death in a time- and concentration-d.... https://www.excli.de/index.php/excli/article/view/3181

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Evaluation of the cytotoxic and immunogenic potential of temozolamide, panobinostat, and Lophophora williamsii extract against C6 glioma cells ; volume:20 ; day:09 ; month:03 ; year:2021 ; EXCLI journal ; 20 (09.03.2021)

Beteiligte, Orts- und Zeitangaben

• Urheber: Franco-Molina, Moises Armides ; Santana-Krímskaya , Silvia Elena ; Madrigal-de-León, Luis Mario ; Coronado-Cerda , Erika Evangelina ; Zárate-Triviño , Diana Ginette ; Hernández-Martínez , Sara Paola ; García-Coronado , Paola Leonor ; Rodríguez-Padilla , Cristina

Weitere Informationen

• DOI: 10.17179/excli2020-3181
• URN: urn:nbn:de:101:1-2021051813405678177100
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:55 MESZ