Effect of L-carnitine against acute mitoxantrone toxicity in mice

Abstract: Various experiments were performed in our laboratory to define a possible role for carnitine derivatives in mitoxantrone (MX) therapy. We report here the results of the effect of L-carnitine (LCAR) on the lethal toxicity of MX in mice. MX was administered intravenously at doses of 7, 9, 11, 13, 15 or 17 mg kg−1 either alone or in combination with LCAR at a single intravenous dose of 200 mg kg−1. The dependence of the probability of death on various doses was evaluated for the MX-LCAR combination compared to MX alone. From these experiments, the following lethal dose fifty (LD50) values were calculated: LD50 for MX alone was 15.2 mg kg−1, whereas in combination with LCAR it increases to 21.8 mg kg−1. The relative toxicity given as the ratio of the LD50 of both MX alone and the combination of MX-LCAR was 69.7%. The results of our experiments unequivocally show the effect of LCAR on acute toxic doses of MX.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Effect of L-carnitine against acute mitoxantrone toxicity in mice ; volume:3 ; number:3 ; year:2008 ; pages:268-272 ; extent:5 ; Open life sciences ; 3, Heft 3 (2008), 268-272 (gesamt 5)

Contributors, Places and Time

• Creator: Niang, Mohamed ; Tomšík, Pavel ; Mělka, Milan ; Stoklasová, Alena ; Cerman, Jaroslav ; Šišpera, Ludìk

Further information

• DOI: 10.2478/s11535-008-0022-9
• URN: urn:nbn:de:101:1-2409201843266.153721070132
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:38 AM CEST