Personalized endoscopic surveillance and intervention protocols for patients with familial adenomatous polyposis: the European FAP Consortium strategy

Background and aims Patients with familial adenomatous polyposis (FAP) undergo colectomy and lifelong endoscopic surveillance to prevent colorectal, duodenal and gastric cancer. Endoscopy has advanced importantly in the past years, including both detection technology as well as treatment options. For the lower gastrointestinal (GI) tract, current guidelines do not provide clear recommendations for surveillance intervals. Furthermore, the Spigelman staging system for duodenal polyposis has its limitations. We present a newly developed personalized endoscopic surveillance strategy for the lower and upper GI tract, aiming to improve the care for patients with FAP. We aim to inform centers caring for FAP patients and encourage the discussion on optimizing endoscopic surveillance and treatment in this high-risk population. Methods The European FAP Consortium, consisting of endoscopists with expertise in FAP, collaboratively developed new surveillance protocols. The proposed strategy was consensus-based and a result of several consortium meetings, discussing current evidence and limitations of existing systems. This strategy provides clear indications for endoscopic polypectomy in the rectum, pouch, duodenum and stomach and defines new criteria for surveillance intervals. This strategy will be evaluated in a 5-year prospective study in 9 FAP expert centers in Europe. Discussion We present a newly developed personalized endoscopic surveillance and endoscopic treatment strategy for patients with FAP aiming to prevent cancer, optimize endoscopic resources and limit the number of surgical interventions. Following this new strategy, prospectively collected data in a large cohort of patients will inform us on the efficacy and safety of the proposed approaches. Trial registration: NCT04678011, NCT04677998

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Personalized endoscopic surveillance and intervention protocols for patients with familial adenomatous polyposis: the European FAP Consortium strategy ; day:11 ; month:01 ; year:2023 ; Endoscopy International Open ; (11.01.2023)

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: Aelvoet, Arthur ; Pellisé, Maria ; Bastiaansen, Barbara A.J. ; van Leerdam, Monique E. ; Jover, Rodrigo ; Balaguer, Francesc ; Kaminski, Michal ; Karstensen, John Gásdal ; Saurin, Jean-Christophe ; Hompes, Roel ; Bossuyt, Patrick M.M. ; Ricciardiello, Luigi ; Latchford, Andrew ; Dekker, Evelien

Weitere Informationen

• DOI: 10.1055/a-2011-1933
• URN: urn:nbn:de:101:1-2023030210145004499726
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:57 MESZ