High‐Density, Conformable Conducting Polymer‐Based Implantable Neural Probes for the Developing Brain
Abstract: Neurologic and neuropsychiatric disorders substantially impact the pediatric population, but there is a lack of dedicated devices for monitoring the developing brain in animal models, leading to gaps in mechanistic understanding of how brain functions emerge and their disruption in disease states. Due to the small size, fragility, and high water content of immature neural tissue, as well as the absence of a hardened skull to mechanically support rigid devices, conventional neural interface devices are poorly suited to acquire brain signals without inducing damage. Here, the authors design conformable, implantable, conducting polymer‐based probes (NeuroShanks) for precise targeting in the developing mouse brain without the need for skull‐attached, rigid mechanical support structures. These probes enable the acquisition of high spatiotemporal resolution neurophysiologic activity from superficial and deep brain regions across unanesthetized behavioral states without causing tissue disruption or device failure. Once implanted, probes are mechanically stable and permit precise, stable signal monitoring at the level of the local field potential and individual action potentials. These results support the translational potential of such devices for clinically indicated neurophysiologic recording in pediatric patients. Additionally, the role of organic bioelectronics as an enabling technology to address questions in developmental neuroscience is revealed.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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High‐Density, Conformable Conducting Polymer‐Based Implantable Neural Probes for the Developing Brain ; day:19 ; month:04 ; year:2024 ; extent:8
Advanced healthcare materials ; (19.04.2024) (gesamt 8)
- Urheber
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Ma, Liang
Wisniewski, Duncan J.
Cea, Claudia
Khodagholy, Dion
Gelinas, Jennifer N.
- DOI
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10.1002/adhm.202304164
- URN
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urn:nbn:de:101:1-2404191419357.088012689268
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:58 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Ma, Liang
- Wisniewski, Duncan J.
- Cea, Claudia
- Khodagholy, Dion
- Gelinas, Jennifer N.
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