Sam37 is crucial for formation of the mitochondrial TOM–SAM supercomplex, thereby promoting β-barrel biogenesis : = Sam37 is crucial for formation of the mitochondrial TOM–SAM supercomplex, thereby promoting [beta]-barrel biogenesis
Abstract: Biogenesis of mitochondrial β-barrel proteins requires two preprotein translocases, the general translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM). TOM and SAM form a supercomplex that promotes transfer of β-barrel precursors. The SAM core complex contains the channel protein Sam50, which cooperates with Sam35 in precursor recognition, and the peripheral membrane protein Sam37. The molecular function of Sam37 has been unknown. We report that Sam37 is crucial for formation of the TOM–SAM supercomplex. Sam37 interacts with the receptor domain of Tom22 on the cytosolic side of the mitochondrial outer membrane and links TOM and SAM complexes. Sam37 thus promotes efficient transfer of β-barrel precursors to the SAM complex. We conclude that Sam37 functions as a coupling factor of the translocase supercomplex of the mitochondrial outer membrane
- Alternative title
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Sam37 is crucial for formation of the mitochondrial TOM–SAM supercomplex, thereby promoting [beta]-barrel biogenesis
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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The journal of cell biology. - 210, 7 (2015) , 1047-1054, ISSN: 0021-9525
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2019
- Creator
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Wenz, Lena-Sophie
Ellenrieder, Lars
Qiu, Jian
Bohnert, Maria
Zufall, Nicole
Laan, Martin van der
Pfanner, Nikolaus
Wiedemann, Nils
Becker, Thomas
- DOI
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10.1083/jcb.201504119
- URN
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urn:nbn:de:bsz:25-freidok-1294294
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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25.03.2025, 1:54 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wenz, Lena-Sophie
- Ellenrieder, Lars
- Qiu, Jian
- Bohnert, Maria
- Zufall, Nicole
- Laan, Martin van der
- Pfanner, Nikolaus
- Wiedemann, Nils
- Becker, Thomas
- Universität
Time of origin
- 2019