Clinical usefulness of circulating tumor markers

Abstract: Tumor markers are a heterogeneous group of substances released by cancer cells into bloodstream, but also expressed by healthy tissues. Thus, very small concentrations can be present in plasma and serum from healthy subjects. Cancer patients tend to show increased levels correlating with tumor bulk, but false positive results could be present in patients with benign conditions. The correct interpretation of TM results could be challenging and many factors should be considered, from pre-analytical conditions to patient concomitant diseases. In this line, the Clinical Chemistry and Laboratory Medicine journal has made important contributions though several publications promoting the adequate use of TM and therefore improving patient safety. TM measurement offers valuable information for cancer patient management in different clinical contexts, such as helping diagnosis, estimating prognosis, facilitating early detection of relapse and monitoring therapy response. Our review analyzes the clinical usefulness of tumor markers applied in most frequent epithelial tumors, based on recent evidence and guidelines.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Clinical usefulness of circulating tumor markers ; volume:61 ; number:5 ; year:2023 ; pages:895-905 ; extent:11 ; Clinical chemistry and laboratory medicine ; 61, Heft 5 (2023), 895-905 (gesamt 11)

Contributors, Places and Time

• Creator: Filella, Xavier ; Rodríguez-Garcia, María ; Fernández-Galán, Esther

Further information

• DOI: 10.1515/cclm-2022-1090
• URN: urn:nbn:de:101:1-2023033114204986465454
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:45 AM CEST