Engineered Biomaterial Platforms to Study Fibrosis
Abstract: Many pathologic conditions lead to the development of tissue scarring and fibrosis, which are characterized by the accumulation of abnormal extracellular matrix (ECM) and changes in tissue mechanical properties. Cells within fibrotic tissues are exposed to dynamic microenvironments that may promote or prolong fibrosis, which makes it difficult to treat. Biomaterials have proved indispensable to better understand how cells sense their extracellular environment and are now being employed to study fibrosis in many tissues. As mechanical testing of tissues becomes more routine and biomaterial tools become more advanced, the impact of biophysical factors in fibrosis are beginning to be understood. Herein, fibrosis from a materials perspective is reviewed, including the role and mechanical properties of ECM components, the spatiotemporal mechanical changes that occur during fibrosis, current biomaterial systems to study fibrosis, and emerging biomaterial systems and tools that can further the understanding of fibrosis initiation and progression. This review concludes by highlighting considerations in promoting wide‐spread use of biomaterials for fibrosis investigations and by suggesting future in vivo studies that it is hoped will inspire the development of even more advanced biomaterial systems.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Engineered Biomaterial Platforms to Study Fibrosis ; volume:9 ; number:8 ; year:2020 ; extent:20
Advanced healthcare materials ; 9, Heft 8 (2020) (gesamt 20)
- Creator
-
Davidson, Matthew D.
Burdick, Jason A.
Wells, Rebecca G.
- DOI
-
10.1002/adhm.201901682
- URN
-
urn:nbn:de:101:1-2022062309125757527520
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Davidson, Matthew D.
- Burdick, Jason A.
- Wells, Rebecca G.
Other Objects (12)
Designing Biomaterial Platforms for Cardiac Tissue and Disease Modeling
Growing Pains: The Need for Engineered Platforms to Study Growth Plate Biology
Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing
Engineered platforms for mimicking cardiac development and drug screening
Modulation of Biomaterial‐Associated Fibrosis by Means of Combined Physicochemical Material Properties
Biomaterial osteoinduction
Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy
Metallic biomaterial interfaces
Using Wool Keratin as a Structural Biomaterial and Natural Mediator to Fabricate Biocompatible and Robust Bioelectronic Platforms
Engineered antigen-presenting hydrogels : model platforms for studies of T cell mechanotransduction
Engineered antigen-presenting hydrogels: model platforms for studies of T cell mechanotransduction
Tissue‐Engineered Cochlear Fibrosis Model Links Complex Impedance to Fibrosis Formation for Cochlear Implant Patients
Designing Biomaterial Platforms for Cardiac Tissue and Disease Modeling
Growing Pains: The Need for Engineered Platforms to Study Growth Plate Biology
Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing
Engineered platforms for mimicking cardiac development and drug screening
Modulation of Biomaterial‐Associated Fibrosis by Means of Combined Physicochemical Material Properties
Biomaterial osteoinduction
Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy
Metallic biomaterial interfaces
Using Wool Keratin as a Structural Biomaterial and Natural Mediator to Fabricate Biocompatible and Robust Bioelectronic Platforms
Engineered antigen-presenting hydrogels : model platforms for studies of T cell mechanotransduction
Engineered antigen-presenting hydrogels: model platforms for studies of T cell mechanotransduction
Tissue‐Engineered Cochlear Fibrosis Model Links Complex Impedance to Fibrosis Formation for Cochlear Implant Patients
Designing Biomaterial Platforms for Cardiac Tissue and Disease Modeling
Growing Pains: The Need for Engineered Platforms to Study Growth Plate Biology
Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing
Engineered platforms for mimicking cardiac development and drug screening
Modulation of Biomaterial‐Associated Fibrosis by Means of Combined Physicochemical Material Properties
Biomaterial osteoinduction
Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy
Metallic biomaterial interfaces
Using Wool Keratin as a Structural Biomaterial and Natural Mediator to Fabricate Biocompatible and Robust Bioelectronic Platforms
Engineered antigen-presenting hydrogels : model platforms for studies of T cell mechanotransduction
Engineered antigen-presenting hydrogels: model platforms for studies of T cell mechanotransduction