Animal models for large vessel vasculitis – The unmet need

Abstract: Our understanding of the pathogenesis of large vessel vasculitis (LVV) are mainly achieved by studying the arteries taken from temporal artery biopsy in giant cell arteries (GCA) or surgical or autopsy specimens in Takayasu arteritis (TAK). These artery specimens provide invaluable information about pathological changes in these conditions that GCA and TAK are similar but are distinctly different in immune cell infiltrate and distribution of inflammatory cells in anatomical locations. However, these specimens of established arteritis do not provide information of the arteritis initiation and early events which are impossible to obtain in human artery specimens. Animal models for LVV are needed but not available. Here, several approaches are proposed for experimentation to generate animal models to aid in delineating the interaction of immune reaction with arterial wall components.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Animal models for large vessel vasculitis – The unmet need ; volume:4 ; number:1 ; year:2023 ; pages:4-10 ; extent:7 ; Rheumatology and immunology research ; 4, Heft 1 (2023), 4-10 (gesamt 7)

Contributors, Places and Time

• Creator: Chu, Cong-Qiu

Further information

• DOI: 10.2478/rir-2023-0002
• URN: urn:nbn:de:101:1-2023041914060351694478
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:00 AM CEST