Molecular fragment characteristics and distribution of tangle associated TDP-43 (TATs) and other TDP-43 lesions in Alzheimer’s disease
Abstract: TAR DNA binding protein 43 (TDP-43) pathology is a defining feature of frontotemporal lobar degeneration (FTLD). In FTLD-TDP there is a moderate-to-high burden of morphologically distinctive TDP-43 immunoreactive inclusions distributed throughout the brain. In Alzheimer’s disease (AD), similar TDP-43 immunoreactive inclusions are observed. In AD, however, there is a unique phenomenon of neurofibrillary tangle-associated TDP-43 (TATs) whereby TDP-43 intermingles with neurofibrillary tangles. Little is known about the characteristics and distribution of TATs, or how burden and distribution of TATs compares to burden and distribution of other FTLD-TDP-like lesions observed in AD. Here we characterize molecular fragment characteristics, burden and distribution of TATs and assess how these features compare to features of other TDP-43 lesions. We performed TDP-43 immunohistochemistry with anti-phosphorylated, C- and N-terminal TDP-43 antibodies in 20 high-probability AD cases and semi-qu.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/5192
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Molecular fragment characteristics and distribution of tangle associated TDP-43 (TATs) and other TDP-43 lesions in Alzheimer’s disease ; volume:4 ; year:2023
Free Neuropathology ; 4 (2023)
- Urheber
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Josephs, Keith A.
Koga, Shunsuke
Tosakulwong, Nirubol
Weigand, Stephen D.
Pham, Nha Trang Thu
Baker, Matt
Whitwell, Jennifer L.
Rademakers, Rosa
Petrucelli, Leonard
Dickson, Dennis W.
- DOI
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10.17879/freeneuropathology-2023-5192
- URN
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urn:nbn:de:hbz:6:3-freeneuropathology-2023-53643
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:52 MESZ
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Beteiligte
- Josephs, Keith A.
- Koga, Shunsuke
- Tosakulwong, Nirubol
- Weigand, Stephen D.
- Pham, Nha Trang Thu
- Baker, Matt
- Whitwell, Jennifer L.
- Rademakers, Rosa
- Petrucelli, Leonard
- Dickson, Dennis W.
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