Severe Refractory Diarrhea Associated with COVID-19: A Case Report
Abstract: Introduction: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is frequently associated with various gastrointestinal symptoms, including abdominal pain, vomiting, and diarrhea. Moreover, several cases of refractory diarrhea have been reported after COVID-19 recovery. Herein, we present a case of severe refractory diarrhea associated with COVID-19. Case Presentation: A 50-year-old man with no comorbidities was admitted to our hospital with SARS-CoV-2 pneumonia. His respiratory status deteriorated, and ventilatory management, including extracorporeal membrane oxygenation, was needed. The patient’s respiratory condition improved, resulting in a transfer to another hospital for rehabilitation. However, the patient developed diarrhea that worsened to 6,000–7,000 mL/day, and he was transferred to our hospital. We diagnosed the patient with enterocolitis caused by cytomegalovirus infection and treated him with ganciclovir on day 5 after transfer to our hospital. The diarrhea did not improve. We suspected enterocolitis associated with COVID-19 and administered a methylprednisolone pulse (intravenous injection, 1,000 mg/day for 3 days) on day 10 after transfer, resulting in a marked improvement in his symptoms. The prednisolone dose was tapered, and no recurrence of diarrhea was observed thereafter. Conclusion: The prevalence of COVID-19-associated enterocolitis is low, and the pathogenesis of the disease remains unclear. Prednisolone administration should be considered in cases of post-COVID-19 symptoms of severe diarrhea due to a possible abnormal immune response related to COVID-19.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Severe Refractory Diarrhea Associated with COVID-19: A Case Report ; volume:18 ; number:1 ; year:2024 ; pages:318-326 ; extent:9
Case reports in gastroenterology ; 18, Heft 1 (2024), 318-326 (gesamt 9)
- Urheber
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Tsuboi, Akiyoshi
Shigenobu, Shuya
Matsubara, Yuka
Hirata, Issei
Tanaka, Hidenori
Yamashita, Ken
Yuge, Ryo
Urabe, Yuji
Arihiro, Koji
Oka, Shiro
- DOI
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10.1159/000539413
- URN
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urn:nbn:de:101:1-2406270053340.144169514228
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:52 MESZ
Datenpartner
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Beteiligte
- Tsuboi, Akiyoshi
- Shigenobu, Shuya
- Matsubara, Yuka
- Hirata, Issei
- Tanaka, Hidenori
- Yamashita, Ken
- Yuge, Ryo
- Urabe, Yuji
- Arihiro, Koji
- Oka, Shiro
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